The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein mediates the signal of the transforming growth factor (TGF)-beta, and thus regulates multiple cellular processes, such as cell proliferation, apoptosis, and differentiation. This protein is recruited to the TGF-beta receptors through its interaction with the SMAD anchor for receptor activation (SARA) protein. In response to TGF-beta signal, this protein is phosphorylated by the TGF-beta receptors. The phosphorylation induces the dissociation of this protein with SARA and the association with the family member SMAD4. The association with SMAD4 is important for the translocation
Catalog No
D12185
Reactivity
Human, Mouse, Rat
Applications
IHC-p, IF(paraffin section), WB
Modification
Acetyl Specific
Source
Polyclonal Rabbit
Dilution
IHC-p 1:50-200, WB 1:500-2000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
Molecular Weight (Da)
Gene Name
Smad2/3 (Acetyl-Lys19)
Protein Name
Smad2/3 (Acetyl-Lys19)
Human Gene ID
4088/4087
Human Swiss Prot No.
Q15796/P84022
Immunogen
Synthesized peptide derived from human Smad2/3 (Acetyl-Lys19)
Specificity
This antibody detects endogenous acetyl levels of Smad2/3 (Acetyl-Lys19) at Human:K19, Mouse:K19, Rat:K19
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
