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Primary Antibodies
TAL1/2 (Acetyl-Lys221/Acetyl-Lys222/Acetyl-Lys36/Acetyl-Lys37) Antibody
TAL1/2 (Acetyl-Lys221/Acetyl-Lys222/Acetyl-Lys36/Acetyl-Lys37) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: D12199
Reactivity:Human,Mouse,Rat
Applications:WB,ELISA
Modification:Acetyl Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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TAL1/2 (Acetyl-Lys221/Acetyl-Lys222/Acetyl-Lys36/Acetyl-Lys37) Antibody

Western blot analysis of MOUSE-HEART MOUSE-BRAIN using Acetyl-TAL1/2 (K221/K222/K36/K37) antibody. Antibody was diluted at 1:500. Secondary antibody(catalog

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Product Details
Product Name
TAL1/2 (Acetyl-Lys221/Acetyl-Lys222/Acetyl-Lys36/Acetyl-Lys37) Antibody
Description
alternative products:The splicing pattern is cell-lineage dependent,disease:A chromosomal aberration involving TAL1 may be a cause of some T-cell acute lymphoblastic leukemias (T-ALL). Translocation t(1;14)(p32;q11) with T-cell receptor alpha chain (TCRA) genes.,domain:The helix-loop-helix domain is necessary and sufficient for the interaction with DRG1.,function:Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation.,PTM:Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia.,PTM:Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells.,similarity:Contains 1 basic helix-loop-helix (bHLH) domain.,subunit:Efficient DNA binding requires dimerization with another bHLH protein. Forms heterodimers with TCF3. Binds to the LIM domain containing protein LMO2 and to DRG1. Can assemble in a complex with LDB1 and LMO2. Component of a TAL-1 complex composed at least of CBFA2T3, LDB1, TAL1 and TCF3.,tissue specificity:Leukemic stem cell.,
Catalog No
D12199
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Acetyl Specific
Applications
WB, ELISA
Dilution
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
TAL1; BHLHA17; SCL; TCL5; T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL2; BHLHA19; T-cell acute lymphocytic leukemia protein 2; TAL-2; Class A basic helix-loop-helix protein 19; bHLHa19
Molecular Weight (Da or kDa)
Gene Name
TAL1/TAL2
Protein Name
T-cell acute lymphocytic leukemia protein 1 homolog/T-cell acute lymphocytic leukemia protein 2
Human Gene ID
6886
Human Swiss Prot No.
P17542
Immunogen
Synthesized acetyl-peptide derived from human TAL1/2 around the acetylation site of K221.
Specificity
Acetyl-TAL1/2 (K221/K222/K36/K37) Polyclonal Antibody detects endogenous levels of TAL1/2 around the acetylation site of K221 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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