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PKR (Phospho-Thr446) Antibody
PKR (Phospho-Thr446) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7198
Reactivity:Human,Rat,Mouse
Applications:WB,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
Product Details
Product Name
PKR (Phospho-Thr446) Antibody
Description
The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2011],
Catalog No
A7198
Reactivity
Human, Rat, Mouse
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
WB, ELISA
Dilution
WB 1:500 - 1:2000. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
EIF2AK2; PKR; PRKR; Interferon-induced; double-stranded RNA-activated protein kinase; Eukaryotic translation initiation factor 2-alpha kinase 2; eIF-2A protein kinase 2; Interferon-inducible RNA-dependent protein kinase; P1/eIF-2A protein k
Molecular Weight (Da or kDa)
Gene Name
EIF2AK2
Protein Name
Interferon-induced double-stranded RNA-activated protein kinase
Human Gene ID
5610
Human Swiss Prot No.
P19525
Immunogen
The antiserum was produced against synthesized peptide derived from human PKR around the phosphorylation site of Thr446. AA range:413-462
Specificity
Phospho-PKR (T446) Polyclonal Antibody detects endogenous levels of PKR protein only when phosphorylated at T446.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (2)