This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Catalog No
A7200
Reactivity
Human, Monkey
Applications
WB, IHC-p, IF(paraffin section), ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PGR; NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3
Molecular Weight (Da)
98981
Gene Name
PGR
Protein Name
Progesterone receptor
Human Gene ID
5241
Human Swiss Prot No.
P06401
Immunogen
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor around the phosphorylation site of Ser190. AA range:161-210
Specificity
Phospho-PR (S190) Polyclonal Antibody detects endogenous levels of PR protein only when phosphorylated at S190.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Western blot analysis of lysates from COS7 cells treated with EGF, using Progesterone Receptor (Phospho-Ser190) Antibody. The lane on the right is blocked with the phospho peptide.
