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Primary Antibodies
p53 Antibody
p53 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: B0529
Reactivity:Human,Mouse,Rat,Monkey
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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Tumor Suppressors/Apoptosis
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p53 Antibody

Immunofluorescence analysis of human-liver tissue. 1,p53 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
p53 Antibody
Description
tumor protein p53(TP53) Homo sapiens This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons (PMIDs: 12032546, 20937277). [provided by RefSeq, Feb 2013],
Catalog No
B0529
Reactivity
Human, Mouse, Rat, Monkey
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
TP53; P53; Cellular tumor antigen p53; Antigen NY-CO-13; Phosphoprotein p53; Tumor suppressor p53
Molecular Weight (Da or kDa)
Gene Name
TP53
Protein Name
Cellular tumor antigen p53
Human Gene ID
7157
Human Swiss Prot No.
P04637
Immunogen
The antiserum was produced against synthesized peptide derived from human p53. AA range:10-59
Specificity
p53 Polyclonal Antibody detects endogenous levels of p53 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (21)
Inhibition of PLK3 Attenuates Tubular Epithelial Cell Apoptosis after Renal Ischemia–Reperfusion Injury by Blocking the ATM/P53-Mediated DNA Damage Response WB Human,Mouse 1 : 1000 kidneys/HK-2 cells

Author: Available in link provided

Date of Publication : Available in link provided

Lianhuaqingwen alleviates p53-mediated apoptosis in alveolar epithelial cells to prevent LPS-induced ALI WB Human 1:5000 /A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

p53 SUMOylation Mediates AOPP-Induced Endothelial Senescence and Apoptosis Evasion.. Frontiers in Cardiovascular Medicine Front Cardiovasc Med. 2021 Jan;8:795747-795747 WB Human,Mouse 1:1000 Aortic tissue HUVECs

Author: Available in link provided

Date of Publication : Available in link provided

Mechanisms Underlying the Effects of Lianhua Qingwen on Sepsis-Induced Acute Lung Injury: A Network Pharmacology Approach. Frontiers in Pharmacology Front Pharmacol. 2021 Oct;0:2839 IHC，WB Mouse 1:250 Lung

Author: Available in link provided

Date of Publication : Available in link provided

Regulation of proliferation and cell cycle by protein regulator of cytokinesis 1 in oral squamous cell carcinoma. Cell Death & Disease 2018 May 11 WB Human 1:500 HSC-2 cell，Cal-27 cell

Author: Available in link provided

Date of Publication : Available in link provided

miR-125a-5p inhibits tumorigenesis in hepatocellular carcinoma. Aging-US Aging-Us. 2019 Sep 30; 11(18): 7639–7662 WB Human Bel-7404 cell， SK-Hep1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Farrerol Attenuates Cisplatin-Induced Nephrotoxicity by Inhibiting the Reactive Oxygen Species-Mediated Oxidation, Inflammation, and Apoptotic Signaling Pathways. Frontiers in Physiology Front Physiol. 2019 Nov;0:1419 WB Mouse kidney MTECs

Author: Available in link provided

Date of Publication : Available in link provided

He-Wei granules (HWKL) combat cisplatin-induced nephrotoxicity and myelosuppression in rats by inhibiting oxidative stress, inflammatory cytokines and apoptosis. RSC Advances Rsc Adv. 2017 Mar;7(32):19794-19807 WB Rat kidney

Author: Available in link provided

Date of Publication : Available in link provided

SPAG6 silencing inhibits the growth of the malignant myeloid cell lines SKM-1 and K562 via activating p53 and caspase activation-dependent apoptosis. INTERNATIONAL JOURNAL OF ONCOLOGY 2015 Feb 01 WB Human 1:500 SKM-1 cell， K562 cell

Author: Available in link provided

Date of Publication : Available in link provided

Targeting FoxM1 by thiostrepton inhibits growth and induces apoptosis of laryngeal squamous cell carcinoma. JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY 2014 Nov 13 WB Human Hep-2 cell

Author: Available in link provided

Date of Publication : Available in link provided

CD90 affects the biological behavior and energy metabolism level of gastric cancer cells by targeting the PI3K/AKT/HIF‑1α signaling pathway. Oncology Letters Oncol Lett. 2021 Mar;21(3):1-1 WB Human 1:1000 AGS cell

Author: Available in link provided

Date of Publication : Available in link provided

DNA damage response-initiated cytokine secretion in bone marrow stromal cells promotes chemoresistance of myeloma cells. LEUKEMIA & LYMPHOMA 2017 Dec 18 WB Human BMSCs

Author: Available in link provided

Date of Publication : Available in link provided

Effects of the combination of As2O3 and AZT on proliferation inhibition and apoptosis induction of hepatoma HepG2 cells following silencing of Egr-1. OncoTargets and Therapy Oncotargets Ther. 2018; 11: 3293–3301 WB Human HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

LC3-II may mediate ATR-induced mitophagy in dopaminergic neurons through SQSTM1/p62 pathway. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2018 Oct 01 WB Rat 1:1000 substantia nigra (SNpc) PC-12 cell

Author: Available in link provided

Date of Publication : Available in link provided

Effects of 12C6+ heavy ion beam irradiation on the p53 signaling pathway in HepG2 liver cancer cells. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2017 Nov 01 WB Human HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib. ONCOLOGY REPORTS 2014 Dec 11 WB Human MDA-MB-468 cell

Author: Available in link provided

Date of Publication : Available in link provided

UBE2W down‐regulation promotes cell apoptosis and correlates with hypospermatogenesis. ANDROLOGIA Andrologia. 2020 Feb;52(1):e13474 WB Mouse 1:2000 testis tissues

Author: Available in link provided

Date of Publication : Available in link provided

Interferon-alpha responsible EPN3 regulates hepatitis B virus replication Frontiers in Medicine Guangyan Liu WB Human,Mouse

Author: Available in link provided

Date of Publication : Available in link provided

Bufalin inhibits the proliferation of lung cancer cells by suppressing Hippo-YAP pathway. Yongchun Yu WB Human A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo CHEMICO-BIOLOGICAL INTERACTIONS Dongjie Li WB Mouse,Rat heart tissue H9c2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Role of DNA damage response in cyclophosphamide-induced premature ovarian failure in mice JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH Yi Song IHC Mouse 1:300 ovary tissue

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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