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Primary Antibodies
mTOR Antibody
mTOR Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: B0688
Reactivity:Human,Mouse,Rat,Bovine,Chicken,Pig
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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mTOR Antibody

Immunohistochemistry analysis of paraffin-embedded human brain tissue, using mTOR Antibody. The picture on the right is blocked with the synthesized peptide.

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Product Details
Product Name
mTOR Antibody
Description
The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as DNA damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008],
Catalog No
B0688
Reactivity
Human, Mouse, Rat, Bovine, Chicken, Pig
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500-2000;IHC 1:100-500;IF ICC 1:100-500;ELISA 1:5000-20000
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
MTOR; FRAP; FRAP1; FRAP2; RAFT1; RAPT1; Serine/threonine-protein kinase mTOR; FK506-binding protein 12-rapamycin complex-associated protein 1; FKBP12-rapamycin complex-associated protein; Mammalian target of rapamycin; mTOR; Mechanistic tar
Molecular Weight (Da or kDa)
Gene Name
MTOR
Protein Name
Serine/threonine-protein kinase mTOR
Human Gene ID
2475
Human Swiss Prot No.
P42345
Immunogen
The antiserum was produced against synthesized peptide derived from human mTOR. AA range:2447-2496
Specificity
mTOR Polyclonal Antibody detects endogenous levels of mTOR protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (36)
CFNC, a neocryptolepine derivative, inhibited the growth of gastric cancer AGS cells by inhibiting PI3K/AKT signaling pathway

Author: Available in link provided

Date of Publication : Available in link provided

MRCKα is a novel regulator of prolactin-induced lactogenesis in bovine mammary epithelial cells WB Bovine 1:1000 /Confluent bovine mammary epithelial cells (BMEC)

Author: Available in link provided

Date of Publication : Available in link provided

Synthesis and anticancer evaluations of novel 1H-imidazole [4,5-f][1,10] phenanthroline derivative for the treatment of colorectal cancer WB Human /HCT116, SW480 cells

Author: Available in link provided

Date of Publication : Available in link provided

Dihydroartemisinin Triggers Ferroptosis in Multidrug-Resistant Leukemia Cells WB Human 1:1000 /K562 cell

Author: Available in link provided

Date of Publication : Available in link provided

Design, synthesis, and cytotoxic activities of isaindigotone derivatives as potential anti-gastric cancer agents. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY2022;37(1):1212-1226. Human AGS cell

Author: Available in link provided

Date of Publication : Available in link provided

Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway Food Chem Toxicol. 2022 May;163:112909. WB Mouse kidney tissue

Author: Available in link provided

Date of Publication : Available in link provided

Insulin Attenuates Beta-Amyloid-Associated Insulin/Akt/EAAT Signaling Perturbations in Human Astrocytes. CELLULAR AND MOLECULAR NEUROBIOLOGY Cell Mol Neurobiol. 2016 Aug;36(6):851-864 WB Human 1:5000 Astrocytes

Author: Available in link provided

Date of Publication : Available in link provided

Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer. Frontiers in Oncology Front Oncol. 2021 Apr;0:352 WB Human 1 : 500 MDA-MB-231/BCRP cell，MDA-MB-453/BCRP cell

Author: Available in link provided

Date of Publication : Available in link provided

Ganoderic acid improves 5-fluorouracil-induced cognitive dysfunction in mice. Food & Function Food Funct. 2021 Nov;: WB Mouse 1:1000 Hippocampus

Author: Available in link provided

Date of Publication : Available in link provided

PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells. International Journal of Biological Sciences Int J Biol Sci. 2018; 14(5): 557–564 WB Human BEASE-2B cell

Author: Available in link provided

Date of Publication : Available in link provided

CD38 is involved in cell energy metabolism via activating the PI3K/AKT/mTOR signaling pathway in cervical cancer cells. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2020 Jul;57(1):338-354 WB Human 1:1000 CaSki cell，Hela cell

Author: Available in link provided

Date of Publication : Available in link provided

Soybean isoflavones prevent atrazine-induced neurodegenerative damage by inducing autophagy. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2020 Mar;190:110065 WB Rat 1:1000 substantia nigra,striatum

Author: Available in link provided

Date of Publication : Available in link provided

Ammonia inhalation-mediated mir-202-5p leads to cardiac autophagy through PTEN/AKT/mTOR pathway. CHEMOSPHERE Chemosphere. 2019 Nov;235:858 WB Chicken 1:500) heart

Author: Available in link provided

Date of Publication : Available in link provided

Targeting glycometabolic reprogramming to restore the sensitivity of leukemia drug-resistant K562/ADM cells to adriamycin. LIFE SCIENCES Life Sci. 2018 Dec;215:1 WB Human 1:1000 K562 cell

Author: Available in link provided

Date of Publication : Available in link provided

Copper induces energy metabolic dysfunction and AMPK-mTOR pathway-mediated autophagy in kidney of broiler chickens. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Ecotox Environ Safe. 2020 Dec;206:111366 WB Chick 1 : 1000 Kidney

Author: Available in link provided

Date of Publication : Available in link provided

Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. CHEMOSPHERE 2017 Dec 06 WB Chicken 1:1000 Spleen

Author: Available in link provided

Date of Publication : Available in link provided

RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1. Cancer Medicine Cancer Med-Us. 2020 Feb;9(4):1529-1543 WB Human 1:2000 RKO cell, SW480 cell, HCT116 cell,LoVo cell

Author: Available in link provided

Date of Publication : Available in link provided

Manganese Chloride Exposure Causes Disorder of Energy Metabolism and Induces Oxidative Stress and Autophagy in Chicken Liver. BIOLOGICAL TRACE ELEMENT RESEARCH Biol Trace Elem Res. 2020 Sep;197(1):254-261 WB Chicken 1:1000 Liver

Author: Available in link provided

Date of Publication : Available in link provided

Anti-apoptotic and apoptotic pathway analysis of arsenic trioxide‑induced apoptosis in human gastric cancer SGC-7901 cells. ONCOLOGY REPORTS 2014 Jun 20 WB Human 1:800 SGC-7901 cell

Author: Available in link provided

Date of Publication : Available in link provided

MicroRNA-7-5p regulates human alveolar epithelial sodium channels by targeting the mTORC2/SGK-1 signaling pathway. EXPERIMENTAL LUNG RESEARCH 2016 Jun 22 WB Human 1:1000 A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Electro-acupuncture attenuates the mice premature ovarian failure via mediating PI3K/AKT/mTOR pathway. LIFE SCIENCES 2018 Dec 03 WB Mouse 1:1000 ovary tissues

Author: Available in link provided

Date of Publication : Available in link provided

The role and regulatory mechanism of autophagy in hippocampal nerve cells of piglet damaged by deoxynivalenol. TOXICOLOGY IN VITRO Toxicol In Vitro. 2020 Aug;66:104837 WB Pig 1:1000 piglet hippocampal nerve cells (PHNCs)

Author: Available in link provided

Date of Publication : Available in link provided

Autophagy enhanced antitumor effect in K562 and K562/ADM cells using realgar transforming solution. BIOMEDICINE & PHARMACOTHERAPY 2017 Dec 27 WB Human K562 cell

Author: Available in link provided

Date of Publication : Available in link provided

Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer. ONCOLOGY REPORTS 2015 Oct 16 WB Human PC-3 cell, DU145 cell

Author: Available in link provided

Date of Publication : Available in link provided

Water‑soluble nano‑pearl powder promotes MC3T3‑E1 cell differentiation by enhancing autophagy via the MEK/ERK signaling pathway. Molecular Medicine Reports Mol Med Rep. 2018 Jul;18(1):993-1000 WB Mouse 1:1000 MC3T3-E1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Glycometabolic adaptation mediates the insensitivity of drug-resistant K562/ADM leukaemia cells to adriamycin via the AKT-mTOR/c-Myc signalling pathway. Molecular Medicine Reports Mol Med Rep. 2017 Apr;15(4):1869-1876 WB Human 1:1000 K562/ADM cell

Author: Available in link provided

Date of Publication : Available in link provided

Outer membrane protein a in Acinetobacter baumannii induces autophagy through mTOR signalling pathways in the lung of SD rats. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2021 Mar;135:111034 IF,IHC,WB Rat 1:100,1: 500,1:100 Lung WTRL1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Zhang, Han, et al. "Kuntai capsule attenuates premature ovarian failure through the PI3K/AKT/mTOR pathway." Journal of ethnopharmacology (2019): 111885.

Author: Available in link provided

Date of Publication : Available in link provided

Cadmium induces BNIP3-dependent autophagy in chicken spleen by modulating miR-33-AMPK axis. CHEMOSPHERE 2017 Dec 06 WB Chicken 1:1000 Spleen

Author: Available in link provided

Date of Publication : Available in link provided

6-Methoxydihydrosanguinarine induces apoptosis and autophagy in breast cancer MCF-7 cells by accumulating ROS to suppress the PI3K/AKT/mTOR signaling pathway PHYTOTHERAPY RESEARCH Hui Zhang WB Human

Author: Available in link provided

Date of Publication : Available in link provided

The natural medicinal fungus Huaier promotes the anti-hepatoma efficacy of sorafenib through the mammalian target of rapamycin-mediated autophagic cell death MEDICAL ONCOLOGY Zhengguang Zhang WB Mouse, Human

Author: Available in link provided

Date of Publication : Available in link provided

UQCRFS1 serves as a prognostic biomarker and promotes the progression of ovarian cancer. Jing Wang WB Human 1:1000 ovarian tissue A2780 cell,OVCAR8 cell

Author: Available in link provided

Date of Publication : Available in link provided

Synthesis of peiminine derivatives and its effect on A549 lung cancer-bearing mice Chemical Biology & Drug Design Xin Jin WB Mouse A549 cell-Xenograft

Author: Available in link provided

Date of Publication : Available in link provided

The Glycyrrhiza glabra L. crude extract alleviates lipid accumulation in NAFLD by activating Nrf2 and promoting autophagy Journal of Functional Foods Yunfei Wei WB Mouse,Human 1:1000 liver tissue HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Glycoursodeoxycholic Acid Alleviates Arterial Thrombosis via Suppressing Diacylglycerol Kinases Activity in Platelet ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY Wenchao Yang WB Mouse platelet pellet

Author: Available in link provided

Date of Publication : Available in link provided

Copper toxicity in the liver of broiler chicken: insights from metabolomics and AMPK-mTOR mediated autophagy perspective POULTRY SCIENCE Jing Chen WB Chicken 1:1000 liver tissue

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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