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Primary Antibodies
ERK 1/2 Antibody
ERK 1/2 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C0185
Reactivity:Human,Mouse,Rat
Applications:IF,WB,IHC,ELISA,ChIP
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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Kinases and Phosphatases
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ERK 1/2 Antibody

Immunofluorescence analysis of human-lung tissue. 1,ERK 1/2 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
ERK 1/2 Antibody
Description
The protein encoded byThis gene is a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act in a signaling cascade that regulates various cellular processes such as proliferation, differentiation, and cell cycle progression in response to a variety of extracellular signals. This kinase is activated by upstream kinases, resulting in its translocation to the nucleus where it phosphorylates nuclear targets. Alternatively spliced transcript variants encoding different protein isoforms have been described. [provided by RefSeq, Jul 2008],
Catalog No
C0185
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
IF, WB, IHC, ELISA, ChIP
Dilution
IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
MAPK1; ERK2; PRKM1; PRKM2; Mitogen-activated protein kinase 1; MAP kinase 1; MAPK 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; MAPK3; MAPK3; ERK1; PRKM3; Mitogen-activated protein kinase 3; MAP kinase 3; MAPK 3; ERT2; Extracellular signal-regulated kinase 1; ERK-1; Insulin-stimulated MAP2 kinase; MAP kinase isoform p44; p44-MAPK; Microtubule-associated protein 2 kinase; p
Molecular Weight (Da or kDa)
Gene Name
MAPK1/MAPK3
Protein Name
Mitogen-activated protein kinase 3
Human Gene ID
5595
Human Swiss Prot No.
P27361 / P28482
Immunogen
The antiserum was produced against synthesized peptide derived from human p44/42 MAPK. AA range:330-379
Specificity
ERK 1/2 Polyclonal Antibody detects endogenous levels of ERK 1/2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (35)
High expression level of CXCL1/GROα is linked to advanced stage and worse survival in uterine cervical cancer and facilitates tumor cell malignant processes WB Human 1:1000 /HeLa cell

Author: Available in link provided

Date of Publication : Available in link provided

Circular RNA circNRIP1 promotes migration and invasion in cervical cancer by sponging miR-629-3p and regulating the PTP4A1/ERK1/2 pathway. Cell Death & Disease Cell Death Dis. 2020 May;11(5):1-15 WB Human HeLa cell,SiHa cell

Author: Available in link provided

Date of Publication : Available in link provided

Telekin suppresses human hepatocellular carcinoma cells in vitro by inducing G 2 /M phase arrest via the p38 MAPK signaling pathway. ACTA PHARMACOLOGICA SINICA Acta Pharmacol Sin. 2014 Sep;35(10):1311-1322 WB Human HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

LASP2 is downregulated in human liver cancer and contributes to hepatoblastoma cell malignant phenotypes through MAPK/ERK pathway. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2020 Jul;127:110154 WB Human 1:1000 HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Effects of hydroxysafflor yellow A on rats with collagen-induced arthritis. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS Biochem Bioph Res Co. 2021 Sep;570:26 WB Rat 1:500 Synovial

Author: Available in link provided

Date of Publication : Available in link provided

Crassifoside H improve the depressive-like behavior of rats under chronic unpredictable mild stress: Possible involved mechanisms. BRAIN RESEARCH BULLETIN Brain Res Bull. 2017 Oct;135:77 WB Rat 1:1000 hippocampus , hypothalamus

Author: Available in link provided

Date of Publication : Available in link provided

Preventative effects of resveratrol and estradiol on streptozotocin-induced diabetes in ovariectomized mice and the related mechanisms. PLoS One 2018 Oct 01 WB Mouse Skeletal muscle,myocardial tissues

Author: Available in link provided

Date of Publication : Available in link provided

Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. BIOORGANIC CHEMISTRY Bioorg Chem. 2020 May;98:103735 ChIP Mouse RAW264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Ad-p53 enhances the sensitivity of triple-negative breast cancer MDA-MB-468 cells to the EGFR inhibitor gefitinib. ONCOLOGY REPORTS 2014 Dec 11 WB Human MDA-MB-468 cell

Author: Available in link provided

Date of Publication : Available in link provided

Matrine inhibits BCR/ABL mediated ERK/MAPK pathway in human leukemia cells. Oncotarget Oncotarget. 2017 Dec 12; 8(65): 108880–108889 WB Human 1:500 ,1:2000 K562 cell, HL-60 cell

Author: Available in link provided

Date of Publication : Available in link provided

The MEK/ERK/CREB signaling pathway is involved in atrazine induced hippocampal neurotoxicity in Sprague Dawley rats. ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY 2018 Dec 20 WB Rat 1:1500 hippocampal tissue

Author: Available in link provided

Date of Publication : Available in link provided

Negative Regulation of Grb10 Interacting GYF Protein 2 on Insulin-Like Growth Factor-1 Receptor Signaling Pathway Caused Diabetic Mice Cognitive Impairment. PLoS One 2014 Sep 30 WB Mouse 1∶1000 hippocampus

Author: Available in link provided

Date of Publication : Available in link provided

Serum proteomics analysis based on label-free revealed the protective effect of Chinese herbal formula Gu-Ben-Fang-Xiao. BIOMEDICINE & PHARMACOTHERAPY Biomed Pharmacother. 2019 Nov;119:109390 WB Mouse 1:1000 lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

CXCL3 overexpression promotes the tumorigenic potential of uterine cervical cancer cells via the MAPK/ERK pathway. JOURNAL OF CELLULAR PHYSIOLOGY J Cell Physiol. 2020 May;235(5):4756-4765 WB Human 1:1000 HeLa cell

Author: Available in link provided

Date of Publication : Available in link provided

SCF/C-KIT signaling modulates tryptase expression in acute myeloid leukemia cells. INTERNATIONAL JOURNAL OF HEMATOLOGY Int J Hematol. 2014 Jun;99(6):750-757 WB Human U937 cell

Author: Available in link provided

Date of Publication : Available in link provided

CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. OncoTargets and Therapy Oncotargets Ther. 2016; 9: 7285–7295 WB Human 1:200 HT-29 cell, SW620 cell

Author: Available in link provided

Date of Publication : Available in link provided

Specific matrix metalloproteinases and calcification factors are associated with the vulnerability of human carotid plaque. Experimental and Therapeutic Medicine 2018 Sep 01 WB Human 1:1000 Carotid plaques

Author: Available in link provided

Date of Publication : Available in link provided

Aβ40 Promotes the Osteoblastic Differentiation of Aortic Valve Interstitial Cells through the RAGE Pathway. Current Medical Science 2020 Oct 29 WB Human 1:1000 Acute aortic aortic valve interstitial cells (AVICs)

Author: Available in link provided

Date of Publication : Available in link provided

SCF/C-KIT signaling modulates tryptase expression in acute myeloid leukemia cells. INTERNATIONAL JOURNAL OF HEMATOLOGY Int J Hematol. 2014 Jun;99(6):750-757 WB Human U937 cell

Author: Available in link provided

Date of Publication : Available in link provided

Specific matrix metalloproteinases and calcification factors are associated with the vulnerability of human carotid plaque. Experimental and Therapeutic Medicine 2018 Sep 01 WB Human 1:1000 Carotid plaques

Author: Available in link provided

Date of Publication : Available in link provided

Ershiwuwei Lvxue Pill alleviates rheumatoid arthritis by different pathways and produces changes in the gut microbiota PHYTOMEDICINE Shaohui Wang WB Rat

Author: Available in link provided

Date of Publication : Available in link provided

Injectable platelet-rich fibrin positively regulates osteogenic differentiation of stem cells from implant hole via the ERK1/2 pathway PLATELETS Lihua Yin WB Human Human bone marrow stem cell (hBMSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways Regenerative Biomaterials Dayun Yang WB Human HuH7 cell,HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

HMGB1 released from dead tumor cells after insufficient radiofrequency ablation promotes progression of HCC residual tumor via ERK1/2 pathway INTERNATIONAL JOURNAL OF HYPERTHERMIA Baoming Luo WB Human HepG2 cell,Huh7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Silencing LCN2 suppresses oral squamous cell carcinoma progression by reducing EGFR signal activation and recycling JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH Zhiquan Huang WB Human CAL-27ER cell,HN-6ER cell,CAL-27 cell,HN-6 cell

Author: Available in link provided

Date of Publication : Available in link provided

FGF12 regulates cell cycle gene expression and promotes follicular granulosa cell proliferation through ERK phosphorylation in geese. Xingyong Chen WB Geese 1:1000 granulosa cell

Author: Available in link provided

Date of Publication : Available in link provided

mGluR1/IP3/ERK signaling pathway regulates vestibular compensation in ON UBCs of the cerebellar flocculus. CNS Neuroscience & Therapeutics Sulin Zhang WB Rat 1:1000 Flocculus tissue

Author: Available in link provided

Date of Publication : Available in link provided

Exploring the role and mechanism of Astragalus membranaceus and radix paeoniae rubra in idiopathic pulmonary fibrosis through network pharmacology and experimental validation. Scientific Reports Quanyu Du IHC Rat lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

Mesenchymal stem cells alleviate sepsis-induced acute lung injury by blocking neutrophil extracellular traps formation and inhibiting ferroptosis in rats PeerJ TieNan Wang WB Rat 1:2000 lung tissue mesenchymal stem cells (MSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Design, synthesis, in vitro and in vivo biological evaluation of pterostilbene derivatives for anti-inflammation therapy JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY Liuzeng Chen WB Mouse 1:1000 RAW264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

The gut microbiota contributes to the infection of bovine viral diarrhea virus in mice JOURNAL OF VIROLOGY Zecai Zhang WB Mouse peripheral blood lymphocytes (PBL)

Author: Available in link provided

Date of Publication : Available in link provided

ETV2 regulating PHD2-HIF-1α axis controls metabolism reprogramming promotes vascularized bone regeneration Bioactive Materials HaoRan Du WB Human 1:1000 dental pulp stem cells (DPSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Bruceantinol works as a CDK2/4/6 inhibitor to inhibit the growth of breast cancer cells CHEMICO-BIOLOGICAL INTERACTIONS Li Sun WB Human MDA-MB-231 cell

Author: Available in link provided

Date of Publication : Available in link provided

LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-κB/RELT signal pathway JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH Wang Hongying WB Mouse RAW264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Silencing miR-155-5p Alleviates Hippocampal Damage in Kainic Acid-Induced Epileptic Rats via the Dusp14/MAPK Pathway BRAIN RESEARCH BULLETIN Qiong Fang WB,IHC Rat 1:500,1:1000 hippocampal tissue

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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