Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class II of the histone deacetylase/acuc/apha family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription. [provided by RefSeq, Jul 2008]
Catalog No
C0226
Reactivity
Human, Mouse
Applications
WB, IHC-p, IF/ICC, ELISA
Modification
Acetyl Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
HDAC6; KIAA0901; JM21; Histone deacetylase 6; HD6
Molecular Weight (Da)
131431
Gene Name
HDAC6
Protein Name
Histone deacetylase 6
Human Gene ID
10013
Human Swiss Prot No.
Q9UBN7
Immunogen
The antiserum was produced against synthesized peptide derived from human HDAC6. AA range:1166-1215
Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue, using HDAC6 Antibody. The picture on the right is blocked with the synthesized peptide.
Author:
Patrick M. McLendona, Bradley S. Fergusonb, Hanna Osinskaa, Md. Shenuarin Bhuiyana, Jeanne Jamesa,
Timothy A. McKinseyb, and Jeffrey Robbinsa,1
Author:
Olga Moreno-Gonzalo, Marta Ramírez-Huesca, Noelia Blas-Rus, Danay Cibrián, María Laura Saiz, Inmaculada Jorge, Emilio Camafeita, Jesús Vázquez, Francisco Sánchez-Madrid
Author:
Norman Núñez-Andrade, Salvador Iborra, Antonio Trullo, Olga Moreno-Gonzalo, Enrique Calvo, Elena Catalán, Gaël Menasche, David Sancho, Jesús Vázquez, Tso-Pang Yao, Noa Beatriz Martín-Cófreces, Francisco Sánchez-Madrid