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Primary Antibodies
MMP-2 Antibody
MMP-2 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C0270
Reactivity:Human,Mouse,Rat,Monkey
Applications:WB,IHC,IF,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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MMP-2 Antibody

Immunofluorescence analysis of rat-lung tissue. 1,MMP-2 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
MMP-2 Antibody
Description
matrix metallopeptidase 2(MMP2) Homo sapiens This gene is a member of the matrix metalloproteinase (MMP) gene family, that are zinc-dependent enzymes capable of cleaving components of the extracellular matrix and molecules involved in signal transduction.The protein encoded by this gene is a gelatinase A, type IV collagenase, that contains three fibronectin type II repeats in its catalytic site that allow binding of denatured type IV and V collagen and elastin. Unlike most MMP family members, activation of this protein can occur on the cell membrane. This enzyme can be activated extracellularly by proteases, or, intracellulary by its S-glutathiolation with no requirement for proteolytical removal of the pro-domain. This protein is thought to be involved in multiple pathways including roles in the nervous system, endometrial menstrual breakdown, regulation of vascularization, and metastasis. Mutations in this gene have been associated with Win
Catalog No
C0270
Reactivity
Human, Mouse, Rat, Monkey
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. IF 1:200 - 1:1000. ELISA: 1:20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
MMP2; CLG4A; 72 kDa type IV collagenase; 72 kDa gelatinase; Gelatinase A; Matrix metalloproteinase-2; MMP-2; TBE-1
Molecular Weight (Da or kDa)
Gene Name
MMP2
Protein Name
72 kDa type IV collagenase
Human Gene ID
4313
Human Swiss Prot No.
P08253
Immunogen
The antiserum was produced against synthesized peptide derived from human MMP-2. AA range:611-660
Specificity
MMP-2 Polyclonal Antibody detects endogenous levels of MMP-2 protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (34)
Methyl-CpG-binding domain 3 inhibits epithelial–mesenchymal transition in pancreatic cancer cells via TGF- β /Smad signalling. BRITISH JOURNAL OF CANCER 2016 Nov 29 WB Human SW1990 cell, PaTu8988 cell, PANC1 cell

Author: Available in link provided

Date of Publication : Available in link provided

LncRNA UCA1 promotes migration and invasion in pancreatic cancer cells via the Hippo pathway. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE 2018 Mar 03 WB Human BxPC-3 cell, SW1990 cell,PaTu8988 cell, PANC-1 cell

Author: Available in link provided

Date of Publication : Available in link provided

GABAergic signaling facilitates breast cancer metastasis by promoting ERK1/2-dependent phosphorylation. CANCER LETTERS Cancer Lett. 2014 Jun;348:100 WB Human 1:1000 breast cancer tissues

Author: Available in link provided

Date of Publication : Available in link provided

MeCP2 suppresses LIN28A expression via binding to its methylated-CpG islands in pancreatic cancer cells. Oncotarget Oncotarget. 2016 Mar 22; 7(12): 14476–14485 WB Human BxPC3 cell, PANC1 cell, SW1990 cell,PaTu8988 cell

Author: Available in link provided

Date of Publication : Available in link provided

PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway. Aging-US Aging-Us. 2020 May 15; 12(9): 7985–8000 WB Mouse 1:1000 HCT-116 cell-Xenograft , SW480 cell-Xenograft HCT-116 cell,SW480 cell

Author: Available in link provided

Date of Publication : Available in link provided

The role of SIRT1 in BMP2-induced chondrogenic differentiation and cartilage maintenance under oxidative stress.. Aging-US Aging-Us. 2020 May 31; 12(10): 9000–9013 WB Mouse 1:500 C3H10T1/2 cells

Author: Available in link provided

Date of Publication : Available in link provided

CBX4 promotes the proliferation and metastasis via regulating BMI‐1 in lung cancer. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE J Cell Mol Med. 2020 Jan;24(1):618-631 WB Human 1:1000 NCI-H460 cell, A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Integration of exosomal miR-106a and mesothelial cells facilitates gastric cancer peritoneal dissemination. CELLULAR SIGNALLING Cell Signal. 2022 Mar;91:110230 WB Human 1:2000 HMrSV5 cell

Author: Available in link provided

Date of Publication : Available in link provided

Uridine-cytidine kinase 2 promotes metastasis of hepatocellular carcinoma cells via the Stat3 pathway. Cancer Management and Research Cancer Manag Res. 2018; 10: 6339–6355 WB Human 1:1000 Bel-7402 cell，Sk-hep-1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Protein arginine methyltransferase 1 coordinates the epithelial-mesenchymal transition/proliferation dichotomy in gastric cancer cells. EXPERIMENTAL CELL RESEARCH 2017 Oct 31 WB Human BGC823 cell, SGC7901 cell,AGS cell, MGC803 cell

Author: Available in link provided

Date of Publication : Available in link provided

YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cells. CELL CYCLE Cell Cycle. 2017;16(23):2259-2271 WB Human SW1990 cell, BxPC3 cell

Author: Available in link provided

Date of Publication : Available in link provided

Acute restraint stress triggers progesterone withdrawal and endometrial breakdown and shedding through corticosterone stimulation in mouse menstrual-like model. REPRODUCTION 2019 Feb 01 IHC Mouse 1:1500 endometrial tissues

Author: Available in link provided

Date of Publication : Available in link provided

Gene silencing of USP1 by lentivirus effectively inhibits proliferation and invasion of human osteosarcoma cells. INTERNATIONAL JOURNAL OF ONCOLOGY 2016 Dec 01 WB Human U2OS cell

Author: Available in link provided

Date of Publication : Available in link provided

Phosphoglycerate mutase 1 knockdown inhibits prostate cancer cell growth, migration, and invasion. ASIAN JOURNAL OF ANDROLOGY Asian J Androl. 2018 Mar-Apr; 20(2): 178–183 WB Human 1:500 PC-3 cell,22Rv1 cell,DU145 cell, LNCap cell

Author: Available in link provided

Date of Publication : Available in link provided

Long non‑coding RNA PVT1 promotes epithelial‑mesenchymal transition via the TGF‑β/Smad pathway in pancreatic cancer cells. ONCOLOGY REPORTS 2018 May 24 WB Human PaTu8988 cell, BxPc-3 cell

Author: Available in link provided

Date of Publication : Available in link provided

Endothelin-1 Activates the Notch Signaling Pathway and Promotes Tumorigenesis in Giant Cell Tumor of the Spine. SPINE Spine. 2019 Sep;44(17):E1000-E1009 WB Human 1:500 giant cell tumor (GCT) tissue

Author: Available in link provided

Date of Publication : Available in link provided

CCL5 secreted from bone marrow stromal cells stimulates the migration and invasion of Huh7 hepatocellular carcinoma cells via the PI3K-Akt pathway. INTERNATIONAL JOURNAL OF ONCOLOGY 2014 May 06 WB Human Huh7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Oleuropein inhibits the proliferation and invasion of glioma cells via suppression of the AKT signaling pathway. ONCOLOGY REPORTS 2016 Jul 28 WB Human U251 cell, A172 cell

Author: Available in link provided

Date of Publication : Available in link provided

CTGF enhances resistance to 5-FU-mediating cell apoptosis through FAK/MEK/ERK signal pathway in colorectal cancer. OncoTargets and Therapy Oncotargets Ther. 2016; 9: 7285–7295 WB Human PaTu8988 cell, SW1990 cell

Author: Available in link provided

Date of Publication : Available in link provided

Emodin suppresses the migration and invasion of melanoma cells. BIOLOGICAL & PHARMACEUTICAL BULLETIN 2021 Mar 17 WB Mouse,Human 1 : 500 B16F10 Melanoma Cells， A375 Melanoma Cells

Author: Available in link provided

Date of Publication : Available in link provided

Paeonol exerts potential activities to inhibit the growth, migration and invasion of human gastric cancer BGC823 cells via downregulating MMP‑2 and MMP‑9. Molecular Medicine Reports Mol Med Rep. 2017 Nov;16(5):7513-7519 WB Human 1:1000 BGC823 cell

Author: Available in link provided

Date of Publication : Available in link provided

Effect of metformin on apoptosis, cell cycle arrest migration and invasion of A498 cells. Molecular Medicine Reports 2014 Mar 31 WB Human A498 cell

Author: Available in link provided

Date of Publication : Available in link provided

Expression of IMP3 as a marker for predicting poor outcome in gastroenteropancreatic neuroendocrine neoplasms. Oncology Letters 2017 Feb 14 IHC Human 1:100 gastroenteropancreatic neuroendocrine neoplasm (GEP‑NEN)

Author: Available in link provided

Date of Publication : Available in link provided

Fang, Zhiqing, et al. "Nitidine chloride inhibits renal cancer cell metastasis via suppressing AKT signaling pathway." Food and chemical toxicology 60 (2013): 246-251.

Author: Available in link provided

Date of Publication : Available in link provided

PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway. Aging-US Aging-Us. 2020 May 15; 12(9): 7985–8000 WB Mouse 1:1000 HCT-116 cell-Xenograft , SW480 cell-Xenograft HCT-116 cell,SW480 cell

Author: Available in link provided

Date of Publication : Available in link provided

Nanocarrier of Pin1 inhibitor based on supercritical fluid technology inhibits cancer metastasis by blocking multiple signaling pathways Regenerative Biomaterials Dayun Yang WB,IHC Human,Mouse lung tissues HuH7 cell,HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

LncRNA FAM83A-AS1 promotes epithelial–mesenchymal transition of pancreatic cancer cells via Hippo pathway. Min Xu WB Human BxPC-3 cell,PANC-1 cell, PaTu8988 cell

Author: Available in link provided

Date of Publication : Available in link provided

Rucaparib inhibits lung adenocarcinoma cell proliferation and migration via the SHCBP1/CDK1 pathway. FEBS Journal Rong Zhang WB Human 1 : 1000 A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

MBD3 promotes epithelial-mesenchymal transition in gastric cancer cells by upregulating ACTG1 via the PI3K/AKT pathway BIOLOGICAL PROCEDURES ONLINE Wang Huizhi WB Human MGC-803 cell,HGC-27 cell

Author: Available in link provided

Date of Publication : Available in link provided

Nupr1-mediated vascular smooth muscle cell phenotype transformation involved in methamphetamine induces pulmonary hypertension CELL BIOLOGY AND TOXICOLOGY Zhou Jie WB Mouse pulmonary arterial smooth muscle cells (PASMCs)

Author: Available in link provided

Date of Publication : Available in link provided

Modulation of epithelial-mesenchymal transition by gemcitabine: Targeting ionizing radiation-induced cellular senescence in lung cancer cell BIOCHEMICAL PHARMACOLOGY Heng Zhou WB,IHC Mouse,Human 1:200 Lewis cell-Xenograft A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Blocking Sigmar1 exacerbates methamphetamine-induced hypertension BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE Zhen-Zhen Xu WB Mouse vascular smooth muscle cell (VSMC),C3H10T1/2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Lnc-216 regulates the miR-143-5p /MMP2 signaling axis aggravates retinal endothelial cell dysfunction CLINICAL HEMORHEOLOGY AND MICROCIRCULATION Wang Fang WB Rat 1:1000 Rat retinal microvascular endothelial cell(RRMEC)

Author: Available in link provided

Date of Publication : Available in link provided

ATP11A Promotes Epithelial-mesenchymal Transition in Gastric Cancer Cells via the Hippo Pathway Journal of Cancer Wang Zhihua WB Human BGC-823 cell,MGC-803 cell,HGC-27 cell,SGC-7901 cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

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