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Primary Antibodies
PI 3-kinase p85/p55 (Phospho-Tyr467/199) Antibody
PI 3-kinase p85/p55 (Phospho-Tyr467/199) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A1224
Reactivity:Human,Mouse,Rat,Monkey
Applications:WB,IHC-p,IF/ICC,ELISA
Modification:Phospho Specific
Source:Polyclonal Rabbit
Storage and Stability:-20°C/1 year

$205
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PI 3-kinase p85/p55 (Phospho-Tyr467/199) Antibody

Western Blot analysis of COS7 cells using Phospho-PI 3-kinase p85/p55 (Y467/199) Polyclonal Antibody diluted at 1:1000

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Product Details
Product Name
PI 3-kinase p85/p55 (Phospho-Tyr467/199) Antibody
Description
Phosphatidylinositol 3-kinase phosphorylates the inositol ring of phosphatidylinositol at the 3-prime position. The enzyme comprises a 110 kD catalytic subunit and a regulatory subunit of either 85, 55, or 50 kD. This gene encodes the 85 kD regulatory subunit. Phosphatidylinositol 3-kinase plays an important role in the metabolic actions of insulin, and a mutation in this gene has been associated with insulin resistance. Alternative splicing of this gene results in four transcript variants encoding different isoforms. [provided by RefSeq, Jun 2011]
Catalog No
A1224
Reactivity
Human, Mouse, Rat, Monkey
Applications
WB, IHC-p, IF/ICC, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alph
Molecular Weight (Da)
83598/54462
Gene Name
PIK3R1/PIK3R3
Protein Name
Phosphatidylinositol 3-kinase regulatory subunit alpha/gamma
Human Gene ID
5295
Human Swiss Prot No.
P27986/Q92569
Immunogen
The antiserum was produced against synthesized peptide derived from human PI3-kinase p85-alpha/gamma around the phosphorylation site of Tyr467/199. AA range:436-485
Specificity
Phospho-PI 3-kinase p85/p55 (Y467/199) Polyclonal Antibody detects endogenous levels of PI 3-kinase p85/p55 protein only when phosphorylated at Y467/199.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (11)
Network Pharmacology Analysis and Experimental Validation to Investigate the Mechanism of Total Flavonoids of Rhizoma Drynariae in Treating Rheumatoid Arthritis

Author: Guang-yao Chen, Jing Luo, Yi Liu, Xin-bo Yu, Xiao-yu Liu, Qing-wen Tao

Date of Publication : 2022-06-08

Integrating Network Pharmacology and Experimental Validation to Explore the Key Mechanism of Gubitong Recipe in the Treatment of Osteoarthritis

Author: Chen Guang-yao, Liu Xiao-yu, Luo Jing, Yu Xin-bo, Liu Yi, Tao Qing-wen

Date of Publication : 2022-06-08

Polygonum cuspidatum Extract Exerts Antihyperlipidemic Effects by Regulation of PI3K/AKT/FOXO3 Signaling Pathway

Author: Tao Ting, Zhang Qing, Liu Zibo, Zhang Ting, Wang Lingyu, Liu Jia, He Tao, Chen Yunhui, Feng Jiayue, Chen Yang

Date of Publication : 2021-12-09

TSSK4 upregulation in alveolar epithelial type-II cells facilitates pulmonary fibrosis through HSP90-AKT signaling restriction and AT-II apoptosis

Author: Chen, Huifang, He, Andong, Li, Haoyang, Chen, Honglv, Xie, Huancheng, Luo, Liping, Huang, Yuyi, Chen, Jiaqian, Guan, Jieying, He, Qiaoling, Ma, Jianjuan, Ou, Changxing, Tao, Ailin, Yan, Jie

Date of Publication : 2021-10-13

Rapamycin Antagonizes BCRP-Mediated Drug Resistance Through the PI3K/Akt/mTOR Signaling Pathway in mPRα-Positive Breast Cancer

Author: Zhang Jing, Hu Jing, Li Weiwei, Zhang Chunyan, Su Peng, Wang Yan, Sun Wei, Wang Xiao, Li Li, Wu Xiaojuan

Date of Publication : 2021-04-12

Regulatory effects of hawthorn polyphenols on hyperglycemic, inflammatory, insulin resistance responses, and alleviation of aortic injury in type 2 diabetic rats

Author: Suwen Liu, Jincheng Yu, Mengfan Fu, Xinfang Wang, Xuedong Chang

Date of Publication : 2021-02-25

Lapatinib‑induced inhibition of ovarian function is counteracted by the STAT3 pathway both in vivo and in vitro

Author: Qiuyue Liao, Xue Feng, Xi Li, Ge Chen, Jing Chen, Bin Yang, Kezhen Li, Jihui Ai

Date of Publication : 2020-09-01

Hydroxy-α-sanshool Possesses Protective Potentials on H2O2-Stimulated PC12 Cells by Suppression of Oxidative Stress-Induced Apoptosis through Regulation of PI3K/Akt Signal Pathway

Author: Li Ruo-Lan, Zhang Qing, Liu Jia, Sun Jia-yi, He Li-Ying, Duan Hu-Xinyue, Peng Wei, Wu Chun-Jie

Date of Publication : 2020-07-09

The role and regulatory mechanism of autophagy in hippocampal nerve cells of piglet damaged by deoxynivalenol

Author: Xichun Wang, Xiaoyan Chu, Li Cao, Jie Zhao, Lei Zhu, Sajid Ur Rahman, Zhen Hu, Yafei Zhang, Shibin Feng, Yu Li, Jinjie Wu

Date of Publication : 2020-03-27

Deficiency in the short‐chain acyl‐CoA dehydrogenase protects mice against diet‐induced obesity and insulin resistance

Author: Yulong Chen, Jinglu Chen, Caixia Zhang, Shanshan Yang, Xueping Zhang, Yin Liu, Zhiguang Su

Date of Publication : 2019-10-04

An Integrated Approach Based on Network Analysis Combined With Experimental Verification Reveals PI3K/Akt/Nrf2 Signaling Is an Important Way for the Anti-Myocardial Ischemia Activity of Yi-Qi-Tong-Luo Capsule.

Author: Huxinyue Duan, Meiyan Li, Jia Liu, Jiayi Sun, Chunjie Wu, Yu Chen, Xiaohui Guo，Xinglong Liu

Date of Publication : 44608

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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