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Primary Antibodies
Caspase-1 Antibody
Caspase-1 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C30122
Reactivity:Human,Mouse,Rat
Applications:IF,WB,IHC,ELISA
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

$205
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Tumor Suppressors/Apoptosis
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Caspase-1 Antibody

Immunofluorescence analysis of rat-lung tissue. 1,Caspase-1 Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
Caspase-1 Antibody
Description
This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce 2 subunits, large and small, that dimerize to form the active enzyme.This gene was identified by its ability to proteolytically cleave and activate the inactive precursor of interleukin-1, a cytokine involved in the processes such as inflammation, septic shock, and wound healing. This gene has been shown to induce cell apoptosis and may function in various developmental stages. Studies of a similar gene in mouse suggest a role in the pathogenesis of Huntington disease. Alternative splicing results in transcript variants encoding distinct isoforms. [provided by RefSeq, Mar 2012],
Catalog No
C30122
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
IF, WB, IHC, ELISA
Dilution
IF 1:50-200 WB 1:500-2000, IHC 1:50-300, ELISA 1:10000-20000
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
caspase 1, apoptosis-related cysteine peptidase (interleukin 1, beta, convertase)
Molecular Weight (Da or kDa)
45kD
Gene Name
CASP1 IL1BC IL1BCE
Protein Name
Caspase1
Human Gene ID
834
Human Swiss Prot No.
P29466
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human CASP1. AA range:350-400
Specificity
Caspase-1 Polyclonal Antibody detects endogenous levels of Caspase-1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (28)
Platelet-rich plasma-derived exosomes attenuate intervertebral disc degeneration by promoting NLRP3 autophagic degradation in macrophages WB Rat 1:1000 /BMDMs

Author: Available in link provided

Date of Publication : Available in link provided

Ras guanine nucleotide-releasing protein-4 promotes renal inflammatory injury in type 2 diabetes mellitus Metabolism. 2022 Feb;:155177. WB Mouse Renal

Author: Available in link provided

Date of Publication : Available in link provided

Crocin alleviates cognitive impairment associated with atherosclerosis via improving neuroinflammation in LDLR−/− mice fed a high-fat/cholesterol diet 2022 Jan 27. WB Mouse 1:1000 hippocampus,parietal cortex

Author: Available in link provided

Date of Publication : Available in link provided

Effects of Hypoxic Environment on Periodontal Tissue through the ROS/TXNIP/NLRP3 Inflammasome Pathway Biomed Res Int. 2022;2022:7690960. WB,IF,IHC Rat ,Human 1 : 1000,1 : 250,1 : 250 Periodontal

Author: Available in link provided

Date of Publication : Available in link provided

Dl-3-n-butylphthalide inhibits neuroinflammation by stimulating foxp3 and Ki-67 in an ischemic stroke model.. Aging-US Aging-Us. 2021 Feb 15; 13(3): 3763–3778 IHC Rat 1:50 Brain

Author: Available in link provided

Date of Publication : Available in link provided

Folic Acid Alleviates High Glucose and Fat-Induced Pyroptosis via Inhibition of the Hippo Signal Pathway on H9C2 Cells. Frontiers in Molecular Biosciences Front Mol Biosci. 2021; 8: 698698 WB Mouse 1:1000 Heart H9C2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Neuroprotective Effects of Safflower Flavonoid Extract in 6-Hydroxydopamine-Induced Model of Parkinson’s Disease May Be Related to its Anti-Inflammatory Action. MOLECULES Molecules. 2020 Jan;25(21):5206 WB Mouse 1:1000 Brain(substantia nigra)

Author: Available in link provided

Date of Publication : Available in link provided

Cereal Fiber Ameliorates High-Fat/Cholesterol-Diet-Induced Atherosclerosis by Modulating the NLRP3 Inflammasome Pathway in ApoE–/– Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J Agr Food Chem. 2018;66(19):4827–4834 WB Mouse 1:1000 aortas

Author: Available in link provided

Date of Publication : Available in link provided

Antitumor Effect of Fluoxetine on Chronic Stress-Promoted Lung Cancer Growth via Suppressing Kynurenine Pathway and Enhancing Cellular Immunity. Frontiers in Pharmacology Front Pharmacol. 2021 Aug;0:1609 WB Mouse 1:2000 A549 cell-xenograft

Author: Available in link provided

Date of Publication : Available in link provided

Apple Polyphenols Extract (APE) Alleviated Dextran Sulfate Sodium Induced Acute Ulcerative Colitis and Accompanying Neuroinflammation via Inhibition of Apoptosis and Pyroptosis. Foods Foods. 2021 Nov;10(11):2711 WB Mouse Colon

Author: Available in link provided

Date of Publication : Available in link provided

MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats. NEUROCHEMICAL RESEARCH Neurochem Res. 2020 Sep;45(9):2020-2031 WB Rat 1:1000 Cortex

Author: Available in link provided

Date of Publication : Available in link provided

Early changes of NLRP3 inflammasome activation after hypoxic-ischemic brain injury in neonatal rats. International Journal of Clinical and Experimental Pathology Int J Clin Exp Patho. 2021; 14(2): 209–220 IHC Rat 1 : 500 Brain

Author: Available in link provided

Date of Publication : Available in link provided

Gynostemma pentaphyllum polysaccharides ameliorate non-alcoholic steatohepatitis in mice associated with gut microbiota and the TLR2/NLRP3 pathway Frontiers in Endocrinology Rui-Rui Wang WB Mouse

Author: Available in link provided

Date of Publication : Available in link provided

Puerarin protects against sepsis-associated encephalopathy by inhibiting NLRP3/Caspase-1/GSDMD pyroptosis pathway and reducing blood-brain barrier damage EUROPEAN JOURNAL OF PHARMACOLOGY Min Zhao IHC Mouse,Rat brain tissues

Author: Available in link provided

Date of Publication : Available in link provided

VX-765 ameliorates CKD VSMC calcification by regulating STAT3 activation EUROPEAN JOURNAL OF PHARMACOLOGY Zhangxiu He IHC，IF Rat abdominal aorta Primary rat VSMCs (rVSMCs)

Author: Available in link provided

Date of Publication : Available in link provided

Hyperhomocysteinemia activates NLRP3 inflammasome to cause hepatic steatosis and insulin resistance via MDM2-mediated ubiquitination of HSF1 INTERNATIONAL IMMUNOPHARMACOLOGY Cheng Zeng IF,WB Mouse,Human liver tissue HepG2 cell

Author: Available in link provided

Date of Publication : Available in link provided

Glucose-driven transformable complex eliminates biofilm and alleviates inflamm-aging for diabetic periodontitis therapy. Bin Liu WB Mouse 1:1500 RAW264.7 ​cell

Author: Available in link provided

Date of Publication : Available in link provided

Induced Neural Stem Cells Suppressed Neuroinflammation by Inhibiting the Microglial Pyroptotic Pathway in Intracerebral Hemorrhage Rats. Xueyun Liang IF Rat,Human 1:300 brain tissue induced neural stem cells (iNSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Phloretin ameliorates heart function after myocardial infarction via NLRP3/Caspase-1/IL-1β signaling. Xuejun Jiang WB Rat 1:1000 cardiac tissue H9c2 Cell

Author: Available in link provided

Date of Publication : Available in link provided

Phloretin ameliorates heart function after myocardial infarction via NLRP3/Caspase-1/IL-1β signaling. Xuejun Jiang WB Rat 1:1000 cardiac tissue H9c2 Cell

Author: Available in link provided

Date of Publication : Available in link provided

Targeting the mechanism of IRF3 in sepsis-associated acute kidney injury via the Hippo pathway. Xingui Dai WB Human HK-2 cell

Author: Available in link provided

Date of Publication : Available in link provided

A novel drug combination of Tofacitinib and Iguratimod alleviates rheumatoid arthritis and secondary osteoporosis. INTERNATIONAL IMMUNOPHARMACOLOGY Qiang Shu IHC Rat 1:100 Synovial tissue,bone tissue

Author: Available in link provided

Date of Publication : Available in link provided

Piceatannol alleviates liver ischaemia/reperfusion injury by inhibiting TLR4/NF-κB/NLRP3 in hepatic macrophages. EUROPEAN JOURNAL OF PHARMACOLOGY Jian Du IHC，IF，WB Mouse 1:50,1:50,1:1000 liver tissue macrophages

Author: Available in link provided

Date of Publication : Available in link provided

Huangqi Baihe Granules alleviate hypobaric hypoxia-induced acute lung injury in rats by suppressing oxidative stress and the TLR4/NF-κB/NLRP3 inflammatory pathway JOURNAL OF ETHNOPHARMACOLOGY Yuanding Zeng WB Rat 1:1000 lung tissue

Author: Available in link provided

Date of Publication : Available in link provided

Blocking CIRP protects against acute pancreatitis by improving mitochondrial function and suppressing pyroptosis in acinar cells Cell Death Discovery Liu Wuming WB Mouse,Rat 1:1000 pancreatic tissue AR42J cell

Author: Available in link provided

Date of Publication : Available in link provided

Dihydroartemisinin-driven TOM70 inhibition leads to mitochondrial destabilization to induce pyroptosis against lung cancer PHYTOTHERAPY RESEARCH Liu-Gen Li WB,IHC Mouse,Human Lewis cell-Xenograft Lewis cell,A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Targeting TANK-binding kinase 1 attenuates painful diabetic neuropathy via inhibiting microglia pyroptosis Cell Communication and Signaling Liao Qinming WB Mouse spinal cord tissue

Author: Available in link provided

Date of Publication : Available in link provided

Icariin suppresses nephrotic syndrome by inhibiting pyroptosis and epithelial-to-mesenchymal transition PLoS One Shuwen Duan WB Rat renal tissue

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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