FA71C Antibody (C40713) | Assay Biotech Inc.

HM74 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: G121

Reactivity:Human,Mouse,Rat

Applications:WB,IF,ELISA

Modification:Unmodified/Total

Source:Polyclonal,Rabbit,IgG

Storage and Stability:Store at -20°C/1 year

Size:

Price/Quantity $205

Quantity:

Datasheet

SDS

Membrane Receptors

HM74 Antibody

Immunofluorescence analysis of MCF7 cells, using GPR109 Antibody. The picture on the right is blocked with the synthesized peptide.

Delivery

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

Telephone

408-747-0185

Fax

408-747-0145

order@assaybiotech.com

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Product Details

Product Name

HM74 Antibody

Description

developmental stage:Expression in neutrophils occurs in the late terminal differentiation phase.,function:Acts as a high affinity receptor for both nicotinic acid (also known as niacin) and (D)-beta-hydroxybutyrate and mediates increased adiponectin secretion and decreased lipolysis through G(i)-protein-mediated inhibition of adenylyl cyclase. This pharmacological effect requires nicotinic acid doses that are much higher than those provided by a normal diet. Mediates nicotinic acid-induced apoptosis in mature neutrophils. Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.,miscellaneous:The rank order of potency for the displacement of nicotinic acid binding is 5-methyl pyrazole-3-carboxylic acid = pyridine-3-acetic acid > acifran > 5-methyl nicotinic acid = acipimox >> nicotinuric acid = nicotinamide.,similarity:Belongs to the G-protein coupled receptor 1 family.,tissue specificity:Expression largely restricted to adipose tissue and spleen. Expressed on mature neutrophils but not on immature neutrophils or eosinophils.,

Catalog No

G121

Reactivity

Human, Mouse, Rat

Source

Polyclonal, Rabbit,IgG

Modification

Unmodified/Total

Applications

WB, IF, ELISA

Dilution

WB 1:500 - 1:2000. IF 1:200 - 1:1000. ELISA: 1:10000. Not yet tested in other applications.

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Storage and Stability

Store at -20°C/1 year

Other Name

HCAR3; GPR109B; HCA3; HM74B; NIACR2; Hydroxycarboxylic acid receptor 3; G-protein coupled receptor 109B; G-protein coupled receptor HM74; G-protein coupled receptor HM74B; Niacin receptor 2; Nicotinic acid receptor 2; HCAR2; GPR109A; HCA2; Hydroxycarboxylic acid receptor 2;

Molecular Weight (Da or kDa)

Gene Name

HCAR2/HCAR3

Protein Name

HM74A/HM74B

Human Gene ID

8843/338442

Human Swiss Prot No.

P49019 / Q8TDS4

Immunogen

The antiserum was produced against synthesized peptide derived from human GPR109. AA range:285-334

Specificity