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Primary Antibodies
MLKL (AB2109) Rabbit mAb
MLKL (AB2109) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M3442
Species Reactivity:Human,Mouse,Rat,
Application:WB,IHC,IF,IP,ELISA
Host:Rabbit
Clonality:Monoclonal
Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

$135
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Recombinant Antibody
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MLKL (AB2109) Rabbit mAb

Various whole cell lysates were separated by 4-20% SDS-PAGE, and the membrane was blotted with anti-MLKL (AB2109) antibody.The HRP-conjugated Goat anti-Rabbit IgG (H + L) antibody was used to detect the antibody. Lane 1: Hela Lane 2: U-251 MG Lane 3: U-14 Lane 4: Rat womb Predicted band size: 55kDa Observed band size: 55kDa

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Product Details
Product Name
MLKL (AB2109) Rabbit mAb
Description
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain, however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3) , which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Catalog No
M3442
Species Reactivity
Human, Mouse, Rat,
Clonality
Monoclonal
Host
Rabbit
Modifcation
Unmodified
Clone
AB2109
Isotype
IgG
Application
WB, IHC, IF, IP, ELISA
Application Dilutions
WB, 1:2000-1:10000 | IHC, 1:1000-1:4000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.
Immunogen
Recombinant protein (or fragment). This information is considered to be commercially sensitive.
Specificity
This antibody detects endogenous levels of MLKL protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.
Purification
The antibody was purified by protein A affinity chromatography.
Storage and Stability
Store at-20℃. Avoid freeze / thaw cycles.
Gene Name
MLKL
Gene ID
197259
Human swiss
Q8NB16
Protein Name
MLKL
Synonyms
MLKL, Mixed lineage kinase domain-like protein
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Primary Antibodies

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    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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