ROCK1 (AB1841) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M3173

Species Reactivity:Human,Mouse,Rat,

Application:WB,IHC,IF,IP,ELISA

Host:Rabbit

Clonality:Monoclonal

Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

Size:

Price/Quantity $135

Quantity:

Datasheet

SDS

Recombinant Antibody

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ROCK1 (AB1841) Rabbit mAb

Delivery

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Lead Time

Antibodies 1-2 business day, ELISA kits 2-3 business day lead time

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408-747-0185

Fax

408-747-0145

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Product Details

Product Name

ROCK1 (AB1841) Rabbit mAb

Description

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. A pseudogene, related to this gene, is also located on chromosome 18. [provided by RefSeq, Aug 2015],

Catalog No

M3173

Species Reactivity

Human, Mouse, Rat,

Clonality

Monoclonal

Host

Rabbit

Modifcation

Unmodified

Clone

AB1841

Isotype

IgG

Application

WB, IHC, IF, IP, ELISA

Application Dilutions

WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5μg-4μg antibody for 200μg-400μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 µg/mL. Please optimize the concentration based on your specific assay requirements.

Immunogen

Recombinant protein (or fragment). This information is considered to be commercially sensitive.

Specificity

This antibody detects endogenous levels of ROCK1 protein.

Formulation

The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% Proclin 300.

Purification

The antibody was purified by protein A affinity chromatography.

Storage and Stability

Store at-20℃. Avoid freeze / thaw cycles.

Gene Name

>>cGMP-PKG signaling pathway, >>cAMP signaling pathway, >>Chemokine signaling pathway, >>Sphingolipid signaling pathway, >>Vascular smooth muscle contraction, >>TGF-beta signaling pathway, >>Axon guidance, >>Focal adhesion, >>Tight junction, >>Platelet activation, >>Leukocyte transendothelial migration, >>Regulation of actin cytoskeleton, >>Oxytocin signaling pathway, >>Pathogenic Escherichia coli infection, >>Shigellosis, >>Yersinia infection, >>Human cytomegalovirus infection, >>Pathways in cancer, >>Proteoglycans in cancer, >>MicroRNAs in cancer

Gene ID

6093

Human swiss

Q13464

Protein Name

ROCK1

Synonyms

ROCK1, Rho-associated protein kinase 1, Renal carcinoma antigen NY-REN-35, Rho-associated, coiled-coil-containing protein kinase 1, Rho-associated, coiled-coil-containing protein kinase I, ROCK-I, p160 ROCK-1, p160ROCK