catalytic activity:ATP + a protein = ADP + a phosphoprotein. , function:Promotes apoptosis and activation of NF-kappa-B. Required for TNFRSF1A mediated activation of NF-kappa-B. , PTM:Autophosphorylated on serine and threonine residues. , PTM:Proteolytically cleaved by caspase-8 during TNF-induced apoptosis. Cleavage abolishes NF-kappa-B activation and enhances pro-apototic signaling through the TRADD-FADD interaction. , similarity:Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. , similarity:Contains 1 death domain. , similarity:Contains 1 protein kinase domain. , subunit:Binds to the death domain of TNFRSF6 and TRADD. Is recruited by TRADD to TNFRSF1A in a TNF-dependent process. Binds RIPK3, UBCE7IP1 isoform 3 (ZIN) , EGFR, IKBKG, TRAF1, TRAF2 and TRAF3. Interacts with BNLF1. Interacts with SQSTM1 upon TNF-alpha stimulation. May interacts with MAVS/IPS1. ,