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Primary Antibodies
MKK3 (Phospho Ser189) +MKK6 (Phospho Ser207) (AB4195) Rabbit mAb
MKK3 (Phospho Ser189) +MKK6 (Phospho Ser207) (AB4195) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M2750
Species Reactivity:Human,Mouse
Application:WB,IF/ICC,ELISA
Host:Rabbit
Clonality:Monoclonal
Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

$150
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Recombinant Antibody
20 ul Size Available
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MKK3 (Phospho Ser189) +MKK6 (Phospho Ser207) (AB4195) Rabbit mAb

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Product Details
Product Name
MKK3 (Phospho Ser189) +MKK6 (Phospho Ser207) (AB4195) Rabbit mAb
Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Catalog No
M2750
Species Reactivity
Human, Mouse
Clonality
Monoclonal
Host
Rabbit
Modifcation
Phospho S189 + S207
Clone
AB4195
Isotype
IgG
Application
WB, IF/ICC, ELISA
Application Dilutions
WB, 1:500-1:1000 | IF/ICC, 1:50-1:200 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Immunogen
A synthetic phosphorylated peptide around S189/S207 of human MKK3/MKK6.
Specificity
The antibody detects endogenous levels of MKK3 protein only when phosphorylated at Ser189 and MKK6 protein phosphorylated at Ser207. The antibody does not cross-react with MKK3 and MKK6 phosphorylated at other sites.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% proclin300.
Purification
The antibody was purified by protein A affinity chromatography.
Storage and Stability
Store at-20℃. Avoid freeze / thaw cycles.
Gene Name
MP2K3/MAP2K3
Gene ID
5606; 5608
Human swiss
P46734; P52564
Protein Name
MKK3 (Phospho Ser189) +MKK6 (Phospho Ser207)
Synonyms
MAP2K3/MAP2K6; Phospho-MKK3-S189+MKK6-S207
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Primary Antibodies

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    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

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