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ZAP70 (Phospho Tyr493) (AB5262) Rabbit mAb
ZAP70 (Phospho Tyr493) (AB5262) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M2267
Species Reactivity:Human
Application:IF/ICC,ELISA
Host:Rabbit
Clonality:Monoclonal
Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

$150
Product Details
Product Name
ZAP70 (Phospho Tyr493) (AB5262) Rabbit mAb
Description
This gene encodes an enzyme belonging to the protein tyrosine kinase family, and it plays a role in T-cell development and lymphocyte activation. This enzyme, which is phosphorylated on tyrosine residues upon T-cell antigen receptor (TCR) stimulation, functions in the initial step of TCR-mediated signal transduction in combination with the Src family kinases, Lck and Fyn. This enzyme is also essential for thymocyte development. Mutations in this gene cause selective T-cell defect, a severe combined immunodeficiency disease characterized by a selective absence of CD8-positive T-cells. Two transcript variants that encode different isoforms have been found for this gene.
Catalog No
M2267
Species Reactivity
Human
Clonality
Monoclonal
Host
Rabbit
Modifcation
Phospho Y493
Clone
AB5262
Isotype
IgG
Application
IF/ICC, ELISA
Application Dilutions
IF/ICC, 1:50-1:200 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Immunogen
A synthetic phosphorylated peptide around Y493 of human ZAP70.
Specificity
The antibody detects endogenous levels of ZAP70 protein only when phosphorylated at Tyr493. The antibody does not cross-react with ZAP70 phosphorylated at other sites.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.05% proclin300.
Purification
The antibody was purified by protein A affinity chromatography.
Storage and Stability
Store at-20℃. Avoid freeze / thaw cycles.
Gene Name
ZAP70
Gene ID
7535
Human swiss
P43403
Protein Name
ZAP70 (Phospho Tyr493)
Synonyms
ZAP70; ADMIO2; IMD48; SRK; STCD; STD; TZK; ZAP-70; tyrosine-protein kinase ZAP-70; Phospho-ZAP70-Y493
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