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DNA topoisomerase II alpha (TOP2A) (AB3317) Rabbit mAb
DNA topoisomerase II alpha (TOP2A) (AB3317) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M0871
Species Reactivity:Human,Mouse
Application:WB,ELISA
Host:Rabbit
Clonality:Monoclonal
Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

$150
Product Details
Product Name
DNA topoisomerase II alpha (TOP2A) (AB3317) Rabbit mAb
Description
This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.
Catalog No
M0871
Species Reactivity
Human, Mouse
Clonality
Monoclonal
Host
Rabbit
Modifcation
Unmodified
Clone
AB3317
Isotype
IgG
Application
WB, ELISA
Application Dilutions
WB, 1:1000-1:6000 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 1432 - 1531 of human DNA topoisomerase II alpha (TOP2A).
Specificity
This antibody detects endogenous levels of DNA topoisomerase II alpha (TOP2A) protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.02% sodium azide.
Purification
The antibody was purified by protein A affinity chromatography.
Storage and Stability
Store at-20℃. Avoid freeze / thaw cycles.
Gene Name
TOP2A
Gene ID
7153
Human swiss
P11388
Protein Name
DNA topoisomerase II alpha (TOP2A)
Synonyms
TOP2; TP2A; TOPIIA; TOP2alpha; DNA topoisomerase II alpha (TOP2A)
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