Enables tumor necrosis factor receptor binding activity. Involved in several processes, including positive regulation of cell communication; positive regulation of macromolecule metabolic process; and positive regulation of neuron death. Located in several cellular components, including external side of plasma membrane; extracellular space; and neuronal cell body. Used to study several diseases, including cerebrovascular disease (multiple) ; liver disease (multiple) ; peptic esophagitis; perinatal necrotizing enterocolitis; and periventricular leukomalacia. Biomarker of several diseases, including brain disease (multiple) ; congestive heart failure (multiple) ; inflammatory bowel disease (multiple) ; lung disease (multiple) ; and non-alcoholic fatty liver disease (multiple) . Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple) ; autoimmune disease (multiple) ; eye disease (multiple) ; lung disease (multiple) ; and skin disease (multiple) . Orthologous to human TNF (tumor necrosis factor) .