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Primary Antibodies
SLC12A1 / NKCC2 (AB4880) Rabbit mAb
SLC12A1 / NKCC2 (AB4880) Rabbit mAb

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: M0165
Species Reactivity:Human,Mouse,Rat
Application:WB,ELISA
Host:Rabbit
Clonality:Monoclonal
Storage and Stability:Store at-20℃. Avoid freeze / thaw cycles.

$150
# Datasheet #
# SDS #
Recombinant Antibody
20 ul Size Available
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SLC12A1 / NKCC2 (AB4880) Rabbit mAb

Western blot analysis of various lysates using SLC12A1 / NKCC2 Rabbit mAb (M0165) at 1:1000 dilution.|Secondary antibody: HRP-conjugated Goat anti-Rabbit IgG (H+L) (SA0002) at 1:10000 dilution.|Lysates/proteins: 25μg per lane.|Blocking buffer: 3% nonfat dry milk in TBST.|Detection: ECL Basic Kit.|Exposure time: 60s.

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Product Details
Product Name
SLC12A1 / NKCC2 (AB4880) Rabbit mAb
Description
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
Catalog No
M0165
Species Reactivity
Human, Mouse, Rat
Clonality
Monoclonal
Host
Rabbit
Modifcation
Unmodified
Clone
AB4880
Isotype
IgG
Application
WB, ELISA
Application Dilutions
WB, 1:500-1:1000 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 601 - 800 of human SLC12A1 / NKCC2 (Q13621).
Specificity
This antibody detects endogenous levels of SLC12A1 / NKCC2 protein.
Formulation
The antibody is provided in liquid form in phosphate - buffered saline with 50% glycerol, 0.05% BSA, and 0.02% sodium azide.
Purification
The antibody was purified by protein A affinity chromatography.
Storage and Stability
Store at-20℃. Avoid freeze / thaw cycles.
Gene Name
SLC12A1
Gene ID
6557
Human swiss
Q13621
Protein Name
SLC12A1 / NKCC2
Synonyms
BSC; BSC1; CCC2; BSC-1; NKCC2; SLC12A1 / NKCC2
Related Products

Catalog No: SA0001

HRP* Goat Anti Mouse IgG(H+L)

Price/Quantity:
$50

Size:
100μL

Catalog No: SA0002

HRP* Goat Anti Rabbit IgG(H+L)

Price/Quantity:
$50

Size:
100μL

Publications (4)
Ferritinophagy is involved in Bisphenol A-induced ferroptosis of renal tubular epithelial cells through the activation of the AMPK-mTOR-ULK1 pathway Food Chem Toxicol. 2022 May;163:112909. WB Mouse kidney tissue

Author: Available in link provided

Date of Publication : Available in link provided

Glucotoxicity Activation of IL6 and IL11 and Subsequent Induction of Fibrosis May Be Involved in the Pathogenesis of Islet Dysfunction. Frontiers in Molecular Biosciences Front Mol Biosci. 2021 Aug;0:793 IHC Rat 1:200 Islet tissue

Author: Available in link provided

Date of Publication : Available in link provided

Hypoxia promotes 786-O cells invasiveness and resistance to sorafenib via HIF-2α/COX-2. MEDICAL ONCOLOGY Med Oncol. 2015 Jan;32(1):1-9 WB Human 786-O cell

Author: Available in link provided

Date of Publication : Available in link provided

Nrf2-mediated redox balance alleviates LPS-induced vascular endothelial cell inflammation by inhibiting endothelial cell ferroptosis Scientific Reports Hou Huimin WB Human 1:1000 Human umbilical vein endothelial cells (HUVEC)

Author: Available in link provided

Date of Publication : Available in link provided

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