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> Products > Primary Antibodies > pVHL (PT0230) mouse mAb

pVHL (PT0230) mouse mAb

Overview Description
Datasheet SDS
   Immunohistochemical   
Catalog No : N1768
  • Reactivity
    Human,Mouse
  • Applications
    IHC-p,IF(paraffin section)
  • Modification
    Unmodfied/ Total
  • Source
    Monoclonal Mouse/IgG3,Kappa
  • Storage and Stability
    -20°C/1 year
  • Size
    50 ul
  • Price/Quantity
    $190
  • Quantity
Add to Cart
Details
  • Product Name
    pVHL (PT0230) mouse mAb
  • Description
    von Hippel-Lindau tumor suppressor(VHL)Homo sapiens. Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
  • Catalog No
    N1768
  • Reactivity
    Human, Mouse
  • Applications
    IHC-p,IF(paraffin section)
  • Modification
    Unmodfied/ Total
  • Source
    Monoclonal Mouse/IgG3, Kappa
  • Dilution
    IHC-p 1:100-500
  • Purification
    The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen.
  • Concentration
  • Storage and Stability
    -20°C/1 year
  • Other Name
  • Molecular Weight (Da)
  • Gene Name
    VHL
  • Protein Name
    Von Hippel-Lindau disease tumor suppressor (Protein G7) (pVHL)
  • Human Gene ID
    7428
  • Human Swiss Prot No.
    P40337
  • Immunogen
    Synthesized peptide derived from human pVHL
  • Specificity
    This antibody detects endogenous levels of human pVHL. Heat-induced epitope retrieval (HIER) TRIS-EDTA of pH8.0 was highly recommended as antigen repair method in paraffin section
  • Formulation
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Application Data
Immunohistochemical analysis of paraffin-embedded Kindey. 1. Antibody was diluted at 1:200(4° overnight). 2. TRIS-EDTA of pH8.0 was used for antigen retrieval. 3.Secondary antibody was diluted at 1:200(room temperature. 30min).
Application Data
Immunohistochemical analysis of paraffin-embedded Kindey. 1. Antibody was diluted at 1:200(4° overnight). 2. TRIS-EDTA of pH8.0 was used for antigen retrieval. 3.Secondary antibody was diluted at 1:200(room temperature. 30min).
Application Data
Immunohistochemical analysis of paraffin-embedded Kindey. 1. Antibody was diluted at 1:200(4° overnight). 2. TRIS-EDTA of pH8.0 was used for antigen retrieval. 3.Secondary antibody was diluted at 1:200(room temperature. 30min).
Application Data
Immunohistochemical analysis of paraffin-embedded Kindey. 1. Antibody was diluted at 1:200(4° overnight). 2. TRIS-EDTA of pH8.0 was used for antigen retrieval. 3.Secondary antibody was diluted at 1:200(room temperature. 30min).

Primary Antibodies

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    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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