tumor protein p73(TP73) Homo sapiens This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Catalog No
D12177
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
Modification
Acetyl Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
TP73; P73; Tumor protein p73; p53-like transcription factor; p53-related protein
Molecular Weight (Da)
69623
Gene Name
TP73
Protein Name
Tumor protein p73
Human Gene ID
7161
Human Swiss Prot No.
O15350
Immunogen
The antiserum was produced against synthesized Acetyl-peptide derived from human p73 around the Acetylation site of Lys327. AA range:291-340
Specificity
Acetyl-p73 (K327) Polyclonal Antibody detects endogenous levels of p73 protein only when acetylated at K327.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
