Myeloperoxidase (MPO) is a heme protein synthesized during myeloid differentiation that constitutes the major component of neutrophil azurophilic granules. Produced as a single chain precursor, myeloperoxidase is subsequently cleaved into a light and heavy chain. The mature myeloperoxidase is a tetramer composed of 2 light chains and 2 heavy chains. This enzyme produces hypohalous acids central to the microbicidal activity of neutrophils. [provided by RefSeq, Nov 2014]
Catalog No
L0124
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
MPO; Myeloperoxidase; MPO
Molecular Weight (Da)
83869
Gene Name
MPO
Protein Name
Myeloperoxidase
Human Gene ID
4353
Human Swiss Prot No.
P05164
Immunogen
Synthesized peptide derived from Cleaved-MPO 89k (A49) . at AA range: 40-120
Specificity
Cleaved-MPO 89k (A49) Polyclonal Antibody detects endogenous levels of fragment of activated MPO 89k protein resulting from cleavage adjacent to A49.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
