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> Products > Primary Antibodies > Cleaved-Spectrin α II (D1185) Antibody

Cleaved-Spectrin α II (D1185) Antibody

Overview Description
Datasheet SDS
   Structural Proteins   
Catalog No : L0134
  • Reactivity
    Human,Rat,Mouse
  • Applications
    WB,ELISA
  • Modification
    Cleaved Specific
  • Source
    Polyclonal Rabbit
  • Storage and Stability
    -20°C/1 year
  • Size
    50 μl
  • Price/Quantity
    $205
  • Quantity
Add to Cart
Details
  • Product Name
    Cleaved-Spectrin α II (D1185) Antibody
  • Description
    Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the Plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010]
  • Catalog No
    L0134
  • Reactivity
    Human, Rat, Mouse
  • Applications
    WB, ELISA
  • Modification
    Cleaved Specific
  • Source
    Polyclonal Rabbit
  • Dilution
    Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
  • Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration
    1 mg/ml
  • Storage and Stability
    -20°C/1 year
  • Other Name
    SPTAN1; NEAS; SPTA2; Spectrin alpha chain; non-erythrocytic 1; Alpha-II spectrin; Fodrin alpha chain; Spectrin, non-erythroid alpha subunit
  • Molecular Weight (Da)
    284539
  • Gene Name
    SPTAN1
  • Protein Name
    Spectrin alpha chain non-erythrocytic 1
  • Human Gene ID
    6709
  • Human Swiss Prot No.
    Q13813
  • Immunogen
    The antiserum was produced against synthesized peptide derived from human SPTA2. AA range:1136-1185
  • Specificity
    Cleaved-Spectrin α II (D1185) Polyclonal Antibody detects endogenous levels of fragment of activated Spectrin α II protein resulting from cleavage adjacent to D1185.
  • Formulation
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Application Data
Western blot analysis of lysates from HeLa and A549 cells, treated with etoposide 25uM 24H, using SPTA2 (Cleaved-Asp1185) Antibody. The lane on the right is blocked with the synthesized peptide.
Application Data
Western Blot analysis of customer's (cat sample) using Cleaved-Spectrin α II (D1185) Polyclonal Antibody diluted at 1:500
Application Data
Western Blot analysis of various cells using Cleaved-Spectrin α II (D1185) Polyclonal Antibody diluted at 1:500
Application Data
Chen, W., Wang, W., Sun, X. et al. NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90. Cell Death Dis 11, 534 (2020). 
Publications

Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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