The protein encoded by this gene is a lysosomal cysteine proteinase and member of the peptidase C1 family. It exhibits both carboxy-monopeptidase and carboxy-dipeptidase activities. The encoded protein has also been known as cathepsin X and cathepsin P. This gene is expressed ubiquitously in cancer cell lines and primary tumors and, like other members of this family, may be involved in tumorigenesis. [provided by RefSeq, Oct 2008]
Catalog No
L0189
Reactivity
Human, Monkey
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
CTSZ; Cathepsin Z; Cathepsin P; Cathepsin X
Molecular Weight (Da)
33868
Gene Name
CTSZ
Protein Name
Cathepsin Z
Human Gene ID
1522
Human Swiss Prot No.
Q9UBR2
Immunogen
The antiserum was produced against synthesized peptide derived from human CATZ. AA range:43-92
Specificity
Cleaved-Cathepsin Z (L62) Polyclonal Antibody detects endogenous levels of fragment of activated Cathepsin Z protein resulting from cleavage adjacent to L62.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Western blot analysis of lysates from COS7 cells, treated with etoposide 25uM 1h, using CATZ (Cleaved-Leu62) Antibody. The lane on the right is blocked with the synthesized peptide.
