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Primary Antibodies
Cleaved-Factor XII HC (I20) Antibody
Cleaved-Factor XII HC (I20) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: L0204
Reactivity:Human,Rat,Mouse
Applications:WB,IHC,IF,ELISA
Modification:Cleaved Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Cleaved-Factor XII HC (I20) Antibody

Immunohistochemistryt analysis of paraffin-embedded human lung carcinoma, using FA12 (heavy chain, Cleaved-Ile20) Antibody. The lane on the right is blocked with the FA12 (heavy chain, Cleaved-Ile20) peptide.

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Product Details
Product Name
Cleaved-Factor XII HC (I20) Antibody
Description
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activat
Catalog No
L0204
Reactivity
Human, Rat, Mouse
Source
Polyclonal, Rabbit,IgG
Modification
Cleaved Specific
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
F12; Coagulation factor XII; Hageman factor; HAF
Molecular Weight (Da or kDa)
68kD
Gene Name
F12
Protein Name
Coagulation factor XII
Human Gene ID
2161
Human Swiss Prot No.
P00748
Immunogen
The antiserum was produced against synthesized peptide derived from human FA12. AA range:1-50
Specificity
Cleaved-Factor XII HC (I20) Polyclonal Antibody detects endogenous levels of fragment of activated Factor XII HC protein resulting from cleavage adjacent to I20.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Primary Antibodies

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    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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