integrin subunit alpha 5(ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Catalog No
L0277
Reactivity
Human, Mouse
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD antigen CD49e
Molecular Weight (Da)
114536
Gene Name
ITGA5
Protein Name
Integrin alpha-5
Human Gene ID
3678
Human Swiss Prot No.
P08648
Immunogen
The antiserum was produced against synthesized peptide derived from human ITGA5. AA range:23-72
Specificity
Cleaved-Integrin α5 HC (F42) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α5 HC protein resulting from cleavage adjacent to F42.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Western blot analysis of lysates from NIH/3T3 cells, treated with etoposide 25uM 24h, using ITGA5 (heavy chain,Cleaved-Phe42) Antibody. The lane on the right is blocked with the synthesized peptide.
