integrin subunit alpha 6(ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with Extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Catalog No
L0282
Reactivity
Human, Rat, Mouse
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD antigen CD49f
Molecular Weight (Da)
126619
Gene Name
ITGA6
Protein Name
Integrin alpha-6
Human Gene ID
3655
Human Swiss Prot No.
P23229
Immunogen
The antiserum was produced against synthesized peptide derived from human ITGA6. AA range:923-972
Specificity
Cleaved-Integrin α6 LC (E942) Polyclonal Antibody detects endogenous levels of fragment of activated Integrin α6 LC protein resulting from cleavage adjacent to E942.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Western blot analysis of lysates from HeLa cells, treated with etoposide 25uM 24h, using ITGA6 (light chain,Cleaved-Glu942) Antibody. The lane on the right is blocked with the synthesized peptide.
