This gene encodes the pro-alpha1 chains of type I collagen whose triple helix comprises two alpha1 chains and one alpha2 chain. Type I is a fibril-forming collagen found in most connective tissues and is abundant in bone, cornea, dermis and tendon. Mutations in this gene are associated with osteogenesis imperfecta types I-IV, Ehlers-Danlos syndrome type VIIA, Ehlers-Danlos syndrome Classical type, Caffey Disease and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor. Two transcripts, resulting from the use of alternate polyadenylation signals, have been identified for this gene. [provided by R. Dalgleish, Feb 2008]
Catalog No
L0412
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
Modification
Cleaved Specific
Source
Polyclonal Rabbit
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
Collagen alpha-1(I) chain (Alpha-1 type I collagen)
Molecular Weight (Da)
161040
Gene Name
COL1A1
Protein Name
Collagen I α1 (Cleaved-Ala1218)
Human Gene ID
1277
Human Swiss Prot No.
P02452
Immunogen
Synthesized peptide derived from human Collagen I α1 (Cleaved-Ala1218)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat Collagen I α1 (Cleaved-Ala1218, protein was cleaved amino acid sequence between 1218-1219 )
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
