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Primary Antibodies
MMP19 (Cleaved-Tyr98) Antibody
MMP19 (Cleaved-Tyr98) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: L0466
Reactivity:Human,Mouse
Applications:WB,IHC
Modification:Cleaved Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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MMP19 (Cleaved-Tyr98) Antibody

Immunohistochemical analysis of paraffin-embedded human liver cancer. 1, Antibody was diluted at 1:200(4° overnight). 2, Tris-EDTA,pH9.0 was used for antigen retrieval. 3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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Product Details
Product Name
MMP19 (Cleaved-Tyr98) Antibody
Description
alternative products:Additional isoforms seem to exist,catalytic activity:Cleaves aggrecan at the 360-Ser-|-Phe-361 site.,cofactor:Binds 1 zinc ion per subunit.,cofactor:Calcium.,disease:May play a role in pathological processes participating in rheumatoid arthritis (RA)-associated joint tissue destruction. Autoantigen anti-MMP19 are frequent in RA patients.,domain:The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.,enzyme regulation:Strongly inhibited by TIMP-2, TIMP-3 and TIMP-4, while TIMP-1 is less efficient.,function:Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin.,PTM:Activated by autolytic cleavage after Lys-97.,similarity:Belongs to the peptidase M10A family.,similarity:Contains 4 hemopexin-like domains.,tissue specificity:Expressed in mammary gland, placenta, lung, pancreas, ovary, small intestine, spleen, thymus, prostate, testis colon, heart and blood vessel walls. Not detected in brain and peripheral blood leukocytes. Also expressed in the synovial fluid of normal and rheumatoid patients.,
Catalog No
L0466
Reactivity
Human, Mouse
Source
Polyclonal, Rabbit,IgG
Modification
Cleaved Specific
Applications
WB, IHC
Dilution
WB 1:500-2000;IHC 1:50-300
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
Matrix metalloproteinase-19 (MMP-19; EC 3.4.24.-; Matrix metalloproteinase RASI; Matrix metalloproteinase-18; MMP-18)
Molecular Weight (Da or kDa)
Gene Name
MMP19 MMP18 RASI
Protein Name
MMP19 (Cleaved-Tyr98)
Human Gene ID
4327
Human Swiss Prot No.
Q99542
Immunogen
Synthesized peptide derived from human MMP19 (Cleaved-Tyr98)
Specificity
This antibody detects endogenous levels of Human,Mouse MMP19 (Cleaved-Tyr98, protein was cleaved amino acid sequence between 97-98 )
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Primary Antibodies

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