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Primary Antibodies
AMPKα1/2 (Phospho-Thr183/172) Antibody
AMPKα1/2 (Phospho-Thr183/172) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A0003
Reactivity:Human,Mouse,Rat,Monkey,Pig
Applications:IF/ICC,WB,IHC-p,ELISA
Modification:Phospho Specific
Source:Polyclonal Rabbit
Storage and Stability:-20°C/1 year

$205
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AMPKα1/2 (Phospho-Thr183/172) Antibody

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Product Details
Product Name
AMPKα1/2 (Phospho-Thr183/172) Antibody
Description
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Catalog No
A0003
Reactivity
Human, Mouse, Rat, Monkey, Pig
Applications
IF/ICC, WB, IHC-p, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
IF: 1:50-200 Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1; PRKAA2; AMPK;
Molecular Weight (Da)
62808/62320
Gene Name
AAPK1/AAPK2
Protein Name
5'-AMP-activated protein kinase catalytic subunit alpha-1/2
Human Gene ID
5562/5563
Human Swiss Prot No.
Q13131/P54646
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189
Specificity
Phospho-AMPKα1/2 (T183/172) Polyclonal Antibody detects endogenous levels of AMPKα1/2 protein only when phosphorylated at T183/172.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (14)
Autophagy and apoptosis mediated nano-copper-induced testicular damage

Author: Helin Chen, Yanyan Wang, Jie Luo, Min Kang, Jin Hou, Ruoping Tang, Ling Zhao, Fei Shi, Gang Ye, Xiaoli He, Hengmin Cui, Hongrui Guo, Yinglun Li, Huaqiao Tang

Date of Publication : 2021-12-15

Bawei Chenxiang Wan Ameliorates Cardiac Hypertrophy by Activating AMPK/PPAR-α Signaling Pathway Improving Energy Metabolism

Author: Zhang Xiaoying, Zhang Zhiying, Wang Pengxiang, Han Yiwei, Liu Lijun, Li Jie, Chen Yichun, Liu Duxia, Wang Jinying, Tian Xiaoying, Zhao Qin, Yan Fengxia

Date of Publication : 2021-06-03

Autophagy was activated against the damages of placentas caused by nano-copper oral exposure

Author: Min Kang, Jie Luo, Ling Zhao, Fei Shi, Gang Ye, Xiaoli He, Suqi Hao, Dan Yang, Helin Chen, Hongrui Guo, Yinglun Li, Huaqiao Tang

Date of Publication : 2021-05-26

Gu-Ben-Fang-Xiao decoction modulates lipid metabolism by activating the AMPK pathway in asthma remission

Author: Yan-Nan You, Qiong-Qiong Xing, Xia Zhao, Jian-Jian Ji, Hua Yan, Tao Zhou, Ying-Mei Dong, Li-Shun Ren, Shu-Ting Hou, Yuan-Yuan Ding

Date of Publication : 2021-03-11

Metformin ameliorates bladder dysfunction in a rat model of partial bladder outlet obstruction

Author: Lipeng Chen, Linchen Lv, Lekai Zhang, Zhengdong Gao, Yaxiao Liu, Shuai Wang, Nan Zhou, Yangyang Xia, Jianfeng Cui, Xuewen Jiang, Xiulin Zhang, Yan Li, Benkang Shi

Date of Publication : 2021-03-01

Outer membrane protein a in Acinetobacter baumannii induces autophagy through mTOR signalling pathways in the lung of SD rats

Author: Dan Zhao, Yumei Li, Chunhong Peng, Jieru Lin, Fuxun Yu, Yichen Zhao, Xiangyan Zhang, Degang Zhao

Date of Publication : 2020-12-31

Overexpression of ATG4a promotes autophagy and proliferation, and inhibits apoptosis in lens epithelial cells via the AMPK and Akt pathways

Author: Chufan Yan, Jiangyue Zhao, Yu Qin, Fangkun Zhao, Liyang Ji, Jinsong Zhang

Date of Publication : 2020-08-01

Dl-3-n-Butylphthalide Promotes Remyelination and Suppresses Inflammation by Regulating AMPK/SIRT1 and STAT3/NF-κB Signaling in Chronic Cerebral Hypoperfusion

Author: Li Meixi, Meng Nan, Guo Xin, Niu Xiaoli, Zhao Zhongmin, Wang Wei, Xie Xiaohua, Lv Peiyuan

Date of Publication : 2020-06-09

SIRT3 deficiency is resistant to autophagy‐dependent ferroptosis by inhibiting the AMPK/mTOR pathway and promoting GPX4 levels

Author: Dandan Han, Lili Jiang, Xiaolong Gu, Shimeng Huang, Jiaman Pang, Yujun Wu, Jingdong Yin, Junjun Wang

Date of Publication : 2020-04-24

TNAP inhibition attenuates cardiac fibrosis induced by myocardial infarction through deactivating TGF-β1/Smads and activating P53 signaling pathways

Author: Gao, Lei, Wang, Li-you, Liu, Zhi-qiang, Jiang, Dan, Wu, Shi-yong, Guo, Yu-qian, Tao, Hong-mei, Sun, Min, You, Lin-na, Qin, Shu, Cheng, Xiao-cheng, Xie, Jun-shi, Chang, Guang-lei, Zhang, Dong-ying

Date of Publication : 2020-01-22

Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases

Author: Hui-Hui Guo, Chen-Lin Feng, Wen-Xuan Zhang, Zhi-Gang Luo, Hong-Juan Zhang, Ting-Ting Zhang, Chen Ma, Yun Zhan, Rui Li, Song Wu, Zeper Abliz, Cong Li, Xiao-Lin Li, Xiao-Lei Ma, Lu-Lu Wang, Wen-Sheng Zheng, Yan-Xing Han, Jian-Dong Jiang

Date of Publication : 2019-04-30

The lncRNA MACC1-AS1 promotes gastric cancer cell metabolic plasticity via AMPK/Lin28 mediated mRNA stability of MACC1

Author: Zhao, Yang, Liu, Yajing, Lin, Li, Huang, Qiong, He, Wanming, Zhang, Shuyi, Dong, Shumin, Wen, Zhaowei, Rao, Jinjun, Liao, Wangjun, Shi, Min

Date of Publication : 2018-03-06

d-Glucose and amino acid deficiency inhibits casein synthesis through JAK2/STAT5 and AMPK/mTOR signaling pathways in mammary epithelial cells of dairy cows

Author: M.C. Zhang, S.G. Zhao, S.S. Wang, C.C. Luo, H.N. Gao, N. Zheng, J.Q. Wang

Date of Publication : 2017-12-14

p53 Mediates Colistin-Induced Autophagy and Apoptosis in PC-12 Cells

Author: Ling Zhang, Daoyuan Xie, Xueping Chen, Maria L. R. Hughes, Guozheng Jiang, Ziyin Lu, Chunli Xia, Li Li, Jinli Wang, Wei Xu, Yuan Sun, Rui Li, Rui Wang, Feng Qian, Jian Li, Jichang Li

Date of Publication : 2016-09-01

Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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