This gene encodes a member of the doublecortin family. The protein encoded by this gene is a Cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ("double cortex" syndrome) in females and lissencephaly ("smooth brain&quo
Catalog No
A0637
Reactivity
Human, Mouse, Rat
Applications
IHC-p, IF(paraffin section), WB
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
IHC-p 1:50-200, WB 1:500-2000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
Neuronal migration protein doublecortin (Doublin) (Lissencephalin-X) (Lis-X)
Molecular Weight (Da)
Gene Name
DCX DBCN LISX
Protein Name
Doublecortin (Phospho-Ser378)
Human Gene ID
1641
Human Swiss Prot No.
O43602
Immunogen
Synthesized peptide derived from human Doublecortin (Phospho-Ser378)
Specificity
This antibody detects endogenous phospho levels of Doublecortin (Phospho-Ser378) at Human:S378, Mouse:S297, Rat:S297
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
