This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. The encoded protein is the major protein of gap junctions in the heart that are thought to have a crucial role in the synchronized contraction of the heart and in embryonic development. A related intronless pseudogene has been mapped to chromosome 5. Mutations in this gene have been associated with oculodentodigital dysplasia, autosomal recessive craniometaphyseal dysplasia and heart malformations. [provided by RefSeq, May 2014]
Catalog No
A0874
Reactivity
Human, Rat, Mouse
Applications
IHC-p, IF(paraffin section), ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
GJA1; GJAL; Gap junction alpha-1 protein; Connexin-43; Cx43; Gap junction 43 kDa heart protein
Molecular Weight (Da)
43008
Gene Name
GJA1
Protein Name
Gap junction alpha-1 protein
Human Gene ID
2697
Human Swiss Prot No.
P17302
Immunogen
The antiserum was produced against synthesized peptide derived from human Connexin 43 around the phosphorylation site of Ser261. AA range:226-275
Specificity
Phospho-Connexin 43 (S261) Polyclonal Antibody detects endogenous levels of Connexin 43 protein only when phosphorylated at S261.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Immunohistochemistry analysis of paraffin-embedded human brain, using Connexin 43 (Phospho-Ser261) Antibody. The picture on the right is blocked with the phospho peptide.
