This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Catalog No
A1070
Reactivity
Human, Mouse, Rat
Applications
IHC-p, IF/ICC, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
ITPR1; INSP3R1; Inositol 1; 4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Molecular Weight (Da)
313945
Gene Name
ITPR1
Protein Name
Inositol 1,4,5-trisphosphate receptor type 1
Human Gene ID
3708
Human Swiss Prot No.
Q14643
Immunogen
The antiserum was produced against synthesized peptide derived from human Inositol 1,4,5-trisphosphate R1 around the phosphorylation site of Ser1598/1588. AA range:1566-1615
Specificity
Phospho-IP3R-I (S1598) Polyclonal Antibody detects endogenous levels of IP3R-I protein only when phosphorylated at S1598.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is blocked with the phospho peptide.
Immunofluorescence analysis of A549 cells, using Inositol 1, 4, 5-trisphosphate R1 (Phospho-Ser1598/1588) Antibody. The picture on the right is blocked with the phospho peptide.
