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Primary Antibodies
AMPKα1 (Phospho-Ser496) Antibody
AMPKα1 (Phospho-Ser496) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7007
Reactivity:Human,Mouse,Rat
Applications:WB,IHC-p,IF(paraffin section),ELISA
Modification:Phospho Specific
Source:Polyclonal Rabbit
Storage and Stability:-20°C/1 year

$205
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AMPKα1 (Phospho-Ser496) Antibody

Western Blot analysis of HELA cells using Phospho-AMPKα1 (S496) Polyclonal Antibody diluted at 1:2000

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Product Details
Product Name
AMPKα1 (Phospho-Ser496) Antibody
Description
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Catalog No
A7007
Reactivity
Human, Mouse, Rat
Applications
WB, IHC-p, IF(paraffin section), ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1
Molecular Weight (Da)
62808
Gene Name
PRKAA1
Protein Name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Human Gene ID
5562
Human Swiss Prot No.
Q13131
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPK1 around the phosphorylation site of Ser496. AA range:451-500
Specificity
Phospho-AMPKα1 (S496) Polyclonal Antibody detects endogenous levels of AMPKα1 protein only when phosphorylated at S496.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (9)
Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice

Author: Deming Li, Zhiqiang Hu, Qian He, Yaxin Guo, Yu Chong, Jiaying Xu, Liqiang Qin

Date of Publication : 2021-12-07

Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats

Author: Xiao-Jun Cao, Rui Wu, He-Ya Qian, Xiang Chen, Hong-Yan Zhu, Guang-Yin Xu, Ye-Zi Sun, Ping-An Zhang

Date of Publication : 2021-09-20

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway

Author: Chunxia Ren, Xinqing Hao, Lu Wang, Yue Hu, Lin Meng, Shize Zheng, Feilong Ren, Wenhuan Bu, Huan Wang, Daowei Li, Kai Zhang, Hongchen Sun

Date of Publication : 2021-05-14

An Integrated Approach Based on Network Pharmacology Combined with Experimental Verification Reveals AMPK/PI3K/Akt Signaling is an Important Way for the Anti-Type 2 Diabetic Activity of Silkworm Excrement

Author: Huxinyue Duan, Qing Zhang, Jia Liu, Ruolan Li, Wei Peng, Chunjie Wu

Date of Publication : 2021-02-11

Silver Nanoparticles Induced Oxidative Stress and Mitochondrial Injuries Mediated Autophagy in HC11 Cells Through Akt/AMPK/mTOR Pathway

Author: Jin Hou, Ling Zhao, Huaqiao Tang, Xiaoli He, Gang Ye, Fei Shi, Min Kang, Helin Chen, Yinglun Li

Date of Publication : 2020-07-14

Epigallocatechin‐3‐gallate activates the AMP‐activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes

Author: Hongyan Ding, Yu Li, Wei Li, Huanqing Tao, Leihong Liu, Cai Zhang, Tao Kong, Shibin Feng, Jinchun Li, Xichun Wang, Jinjie Wu

Date of Publication : 2020-06-22

LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway

Author: Jie Shi, Rongqin Dai, Yuqing Chen, Honggang Guo, Yinyin Han, Yin Zhang

Date of Publication : 2019-08-05

Effects of Metformin Combined with Lactoferrin on Lipid Accumulation and Metabolism in Mice Fed with High-Fat Diet

Author: Qing-Qing Min, Li-Qiang Qin, Zhen-Zhen Sun, Wen-Ting Zuo, Lin Zhao, Jia-Ying Xu

Date of Publication : 2018-11-02

PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells

Author: Xiao-Ming Zhu, Qin Wang, Wei-Wei Xing, Min-Hui Long, Wen-Liang Fu, Wen-Rong Xia, Chen Jin, Ning Guo, Dong-Qun Xu, Dong-Gang Xu

Date of Publication : 2018-04-05

Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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