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Primary Antibodies
AMPKα1 (Phospho-Ser496) Antibody
AMPKα1 (Phospho-Ser496) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7007
Reactivity:Human,Mouse,Rat,Canine,Fish
Applications:WB,IHC,IF,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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AMPKα1 (Phospho-Ser496) Antibody

Immunohistochemistry analysis of paraffin-embedded human colon carcinoma, using AMPK1 (Phospho-Ser485) Antibody. The picture on the right is blocked with the phospho peptide.

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Product Details
Product Name
AMPKα1 (Phospho-Ser496) Antibody
Description
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008],
Catalog No
A7007
Reactivity
Human, Mouse, Rat, Canine, Fish
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
WB, IHC, IF, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:20000.. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
PRKAA1; AMPK1; 5'-AMP-activated protein kinase catalytic subunit alpha-1; AMPK subunit alpha-1; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase; Tau-protein kinase PRKAA1
Molecular Weight (Da or kDa)
Gene Name
PRKAA1
Protein Name
5'-AMP-activated protein kinase catalytic subunit alpha-1
Human Gene ID
5562
Human Swiss Prot No.
Q13131
Immunogen
The antiserum was produced against synthesized peptide derived from human AMPK1 around the phosphorylation site of Ser496. AA range:451-500
Specificity
Phospho-AMPKα1 (S496) Polyclonal Antibody detects endogenous levels of AMPKα1 protein only when phosphorylated at S496.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (10)
Effects of Metformin Combined with Lactoferrin on Lipid Accumulation and Metabolism in Mice Fed with High-Fat Diet. Nutrients Nutrients. 2018 Nov;10(11):1628 WB Mouse 1:500 Liver tissue

Author: Available in link provided

Date of Publication : Available in link provided

Metformin Carbon Dots for Promoting Periodontal Bone Regeneration via Activation of ERK/AMPK Pathway. Advanced Healthcare Materials Adv Healthc Mater. 2021 Jun;10(12):2100196 WB Rat Rat bone marrow mesenchymal stem cells (rBMSCs)

Author: Available in link provided

Date of Publication : Available in link provided

Epigallocatechin‐3‐gallate activates the AMP‐activated protein kinase signaling pathway to reduce lipid accumulation in canine hepatocytes. JOURNAL OF CELLULAR PHYSIOLOGY J Cell Physiol. 2021 Jan;236(1):405-416 WB Canine 1:500 Hepatocytes

Author: Available in link provided

Date of Publication : Available in link provided

LncRNA LINP1 regulates acute myeloid leukemia progression via HNF4α/AMPK/WNT5A signaling pathway. HEMATOLOGICAL ONCOLOGY Hematol Oncol. 2019 Oct;37(4):474-482 WB Human THP-1 cell,KG-1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Lactoferrin Alleviates Acute Alcoholic Liver Injury by Improving Redox-Stress Response Capacity in Female C57BL/6J Mice. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY J Agr Food Chem. 2021;69(49):14856–14867 WB Mouse 1:1000 Liver

Author: Available in link provided

Date of Publication : Available in link provided

Metformin attenuates diabetic neuropathic pain via AMPK/NF-κB signaling pathway in dorsal root ganglion of diabetic rats. BRAIN RESEARCH Brain Res. 2021 Dec;1772:147663 WB Rat 1:500 L4-7 DRGs

Author: Available in link provided

Date of Publication : Available in link provided

Silver Nanoparticles Induced Oxidative Stress and Mitochondrial Injuries Mediated Autophagy in HC11 Cells Through Akt/AMPK/mTOR Pathway. BIOLOGICAL TRACE ELEMENT RESEARCH Biol Trace Elem Res. 2021 Mar;199(3):1062-1073 WB Human 1 : 1000 HC11 cell

Author: Available in link provided

Date of Publication : Available in link provided

PM2.5 induces autophagy-mediated cell death via NOS2 signaling in human bronchial epithelium cells. International Journal of Biological Sciences Int J Biol Sci. 2018; 14(5): 557–564 WB Human BEASE-2B cell

Author: Available in link provided

Date of Publication : Available in link provided

Klotho improves cardiac fibrosis, inflammatory cytokines, ferroptosis, and oxidative stress in mice with myocardial infarction JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY Di XU WB Mouse,Rat peri-infarct myocardial tissue H9C2 cells

Author: Available in link provided

Date of Publication : Available in link provided

Physiological responses to acute hypoxia in the liver of largemouth bass by alteration of mitochondrial function and Ca2+ exchange AQUATIC TOXICOLOGY Song Yang WB Fish Liver tissue

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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