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Primary Antibodies
eIF2α (Phospho-Ser51) Antibody
eIF2α (Phospho-Ser51) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7066
Reactivity:Human,Mouse,Rat,Dog,Pig,Fish
Applications:IF,WB,IHC,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

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eIF2α (Phospho-Ser51) Antibody

Immunofluorescence analysis of rat-heart tissue. 1,eIF2α (phospho Ser51) Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
eIF2α (Phospho-Ser51) Antibody
Description
The translation initiation factor EIF2 catalyzes the first regulated step of protein synthesis initiation, promoting the binding of the initiator tRNA to 40S ribosomal subunits. Binding occurs as a ternary complex of methionyl-tRNA, EIF2, and GTP. EIF2 is composed of 3 nonidentical subunits, the 36-kD EIF2-alpha subunit (EIF2S1), the 38-kD EIF2-beta subunit (EIF2S2; MIM 603908), and the 52-kD EIF2-gamma subunit (EIF2S3; MIM 300161). The rate of formation of the ternary complex is modulated by the phosphorylation state of EIF2-alpha (Ernst et al., 1987 [PubMed 2948954]).[supplied by OMIM, Feb 2010],
Catalog No
A7066
Reactivity
Human, Mouse, Rat, Dog, Pig, Fish
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
IF, WB, IHC, ELISA
Dilution
IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
EIF2S1; EIF2A; Eukaryotic translation initiation factor 2 subunit 1; Eukaryotic translation initiation factor 2 subunit alpha; eIF-2-alpha; eIF-2A; eIF-2alpha
Molecular Weight (Da or kDa)
Gene Name
EIF2S1
Protein Name
Eukaryotic translation initiation factor 2 subunit 1
Human Gene ID
1965
Human Swiss Prot No.
P05198
Immunogen
The antiserum was produced against synthesized peptide derived from human eIF2 alpha around the phosphorylation site of Ser51. AA range:21-70
Specificity
Phospho-eIF2α (S51) Polyclonal Antibody detects endogenous levels of eIF2α protein only when phosphorylated at S51.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (16)
Promotion of osteogenesis in BMSC under hypoxia by ATF4 via the PERK–eIF2α signaling pathway

Author: Available in link provided

Date of Publication : Available in link provided

Huaier Induces Immunogenic Cell Death Via CircCLASP1/PKR/eIF2α Signaling Pathway in Triple Negative Breast Cancer WB Human /MDA-MB-231 cells

Author: Available in link provided

Date of Publication : Available in link provided

Citrus alkaline extracts prevent endoplasmic reticulum stress in type II alveolar epithelial cells to ameliorate pulmonary fibrosis via the ATF3/PINK1 pathway. PHYTOMEDICINE Phytomedicine. 2021 Aug;89:153599 WB Human 1 : 1000 Lung A549 cell

Author: Available in link provided

Date of Publication : Available in link provided

Stress kinases, endoplasmic reticulum stress, and Alzheimer’s disease related markers in peripheral blood mononuclear cells from subjects with increased body weight. Scientific Reports 2016 Aug 02 WB Human PBMCs

Author: Available in link provided

Date of Publication : Available in link provided

PERK signalling pathway mediates single prolonged stress-induced dysfunction of medial prefrontal cortex neurons. APOPTOSIS Apoptosis. 2017 Jun;22(6):753-768 WB Rat 1:500 neurons

Author: Available in link provided

Date of Publication : Available in link provided

Overexpression of long non‐coding RNA NORAD promotes invasion and migration in malignant melanoma via regulating the MIR‐205‐EGLN2 pathway. Cancer Medicine Cancer Med-Us. 2019 Apr;8(4):1744-1754 WB Human A375 cell, WM35 cell

Author: Available in link provided

Date of Publication : Available in link provided

Effects of vitamin D and resveratrol on metabolic associated markers in liver and adipose tissue from SAMP8 mice. EXPERIMENTAL GERONTOLOGY 2017 Apr 12 WB Mouse liver, epididymal ,subcutaneous adipose tissue

Author: Available in link provided

Date of Publication : Available in link provided

HRI of Epinephelus coioides is a critical factor in the grouper immune response to RGNNV infection. FISH & SHELLFISH IMMUNOLOGY 2019 Feb 10 WB Fish 1:1000 Grouper spleen (GS) cell

Author: Available in link provided

Date of Publication : Available in link provided

Isorhamnetin protects against bleomycin-induced pulmonary fibrosis by inhibiting endoplasmic reticulum stress and epithelial-mesenchymal transition. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE 2019 Jan 01 WB Human,Mouse 1:1000 lung A549 cell,HBECs

Author: Available in link provided

Date of Publication : Available in link provided

Rce1 expression in renal cell carcinoma and its regulatory effect on 786-O cell apoptosis through endoplasmic reticulum stress. ACTA BIOCHIMICA ET BIOPHYSICA SINICA 2017 Mar 01 WB Human 1:2000 renal cancer tissues 786-O cell

Author: Available in link provided

Date of Publication : Available in link provided

Cheng, Jinbo, et al. "Vitamin D combined with resveratrol prevents cognitive decline in SAMP8 mice." Current Alzheimer Research 14.8 (2017): 820-833.

Author: Available in link provided

Date of Publication : Available in link provided

Combination of histidine, lysine, methionine, and leucine promotes β-casein synthesis via the mechanistic target of rapamycin signaling pathway in bovine mammary epithelial cells." Journal of dairy science 100.9 (2017): 7696-7709.

Author: Available in link provided

Date of Publication : Available in link provided

Cadmium induces liver dysfunction and ferroptosis through the endoplasmic stress-ferritinophagy axis ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY Jiacheng Wu WB Mouse

Author: Available in link provided

Date of Publication : Available in link provided

Fusaric acid inhibits proliferation and induces apoptosis through triggering endoplasmic reticulum stress in MCF-7 human breast cancer cells. Yao Xiaoqiang WB Human 1:1000 MCF-7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Ascomylactam C Induces an Immunogenic Cell Death Signature via Mitochondria-Associated ER Stress in Lung Cancer and Melanoma Marine Drugs Yun Huang WB Human,Mouse 1:500 A549 cell,LLC cell,A375 cell,B16F10 cell

Author: Available in link provided

Date of Publication : Available in link provided

Ferroptosis is involved in Staphylococcus aureus-induced mastitis through autophagy activation by endoplasmic reticulum stress INTERNATIONAL IMMUNOPHARMACOLOGY Lijuan Bao WB Mouse 1:1000 Mouse mammary epithelial cell(MMEC)

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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