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Primary Antibodies
JAK1 (Phospho-Tyr1022) Antibody
JAK1 (Phospho-Tyr1022) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7125
Reactivity:Human,Mouse,Rat
Applications:IF,WB,IP,IHC,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Kinases and Phosphatases
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JAK1 (Phospho-Tyr1022) Antibody

Immunofluorescence analysis of mouse-liver tissue. 1,JAK1 (phospho Tyr1022) Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
JAK1 (Phospho-Tyr1022) Antibody
Description
This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta and interferon-gamma signal transduction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016],
Catalog No
A7125
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
IF, WB, IP, IHC, ELISA
Dilution
IF 1:50-200 WB 1:200 - 1:1000. IHC 1:100 - 1:300. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
JAK1; JAK1A; JAK1B; Tyrosine-protein kinase JAK1; Janus kinase 1; JAK-1
Molecular Weight (Da or kDa)
Gene Name
JAK1
Protein Name
Tyrosine-protein kinase JAK1
Human Gene ID
3716
Human Swiss Prot No.
P23458
Immunogen
The antiserum was produced against synthesized peptide derived from human JAK1 around the phosphorylation site of Tyr1022. AA range:988-1037
Specificity
Phospho-JAK1 (Y1022) Polyclonal Antibody detects endogenous levels of JAK1 protein only when phosphorylated at Y1022.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (8)
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses. Nature Communications Nat Commun. 2020 Apr;11(1):1-16 WB Mouse 1:1000 BMDMs

Author: Available in link provided

Date of Publication : Available in link provided

Treadmill Exercise Attenuates Cerebral Ischemia–Reperfusion Injury by Promoting Activation of M2 Microglia via Upregulation of Interleukin-4. Frontiers in Cardiovascular Medicine Front Cardiovasc Med. 2021 Oct;0:1282 WB Rat 1:500 Penumbra

Author: Available in link provided

Date of Publication : Available in link provided

Herpes Simplex Virus 1 UL36USP Antagonizes Type I Interferon-Mediated Antiviral Innate Immunity. JOURNAL OF VIROLOGY J Virol. 2018 Oct;: IP Human HEK293T cell

Author: Available in link provided

Date of Publication : Available in link provided

Paeoniflorin‐6′‐o‐benzene sulfonate (CP‐25) improves vasculitis through inhibiting IL‐17A/JAK/STAT3 signaling pathway in endothelial cells of HFD CIA rats. PHYTOTHERAPY RESEARCH Phytother Res. 2021 Feb;35(2):1033-1047 WB Human 1 : 500 HUVECs

Author: Available in link provided

Date of Publication : Available in link provided

C6orf120 gene knockout in rats mitigates concanavalin A‑induced autoimmune hepatitis via regulating NKT cells. CELLULAR IMMUNOLOGY Cell Immunol. 2022 Jan;371:104467 WB Rat Liver

Author: Available in link provided

Date of Publication : Available in link provided

Novel paeonol derivatives: Design, synthesis and anti-inflammatory activity in vitro and in vivo. BIOORGANIC CHEMISTRY Bioorg Chem. 2020 May;98:103735 WB Mouse RAW264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Alpha-Momorcharin Inhibits Proinflammatory Cytokine Expression by M1 Macrophages but Not Anti-Inflammatory Cytokine Expression by M2 Macrophages Journal of Inflammation Research Fubing Shen WB Human

Author: Available in link provided

Date of Publication : Available in link provided

Phillygenin inhibited M1 macrophage polarization and reduced hepatic stellate cell activation by inhibiting macrophage exosomal miR-125b-5p BIOMEDICINE & PHARMACOTHERAPY Cheng Ma WB Mouse RAW264.7 cells

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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