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MEK-2 (Phospho-Thr394) Antibody
MEK-2 (Phospho-Thr394) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7149
Reactivity:Human,Mouse,Rat
Applications:WB,IHC,IF,IP,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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MEK-2 (Phospho-Thr394) Antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma, using MEK2 (Phospho-Thr394) Antibody. The picture on the right is blocked with the phospho peptide.

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Product Details
Product Name
MEK-2 (Phospho-Thr394) Antibody
Description
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases. Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene. [provided by RefSeq, Jul 2008],
Catalog No
A7149
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
WB, IHC, IF, IP, ELISA
Dilution
WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. ELISA: 1:10000.. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
MAP2K2; MEK2; MKK2; PRKMK2; Dual specificity mitogen-activated protein kinase kinase 2; MAP kinase kinase 2; MAPKK 2; ERK activator kinase 2; MAPK/ERK kinase 2; MEK 2
Molecular Weight (Da or kDa)
44kD
Gene Name
MAP2K2
Protein Name
Dual specificity mitogen-activated protein kinase kinase 2
Human Gene ID
5606
Human Swiss Prot No.
P36507
Immunogen
The antiserum was produced against synthesized peptide derived from human MEK2 around the phosphorylation site of Thr394. AA range:261-310
Specificity
Phospho-MEK-2 (T394) Polyclonal Antibody detects endogenous levels of MEK-2 protein only when phosphorylated at T394.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (2)
Identification of WISP1 as a novel oncogene in glioblastoma. INTERNATIONAL JOURNAL OF ONCOLOGY Int J Oncol. 2017 Oct;51(4):1261-1270 WB Human 1:1000 U251 cell, U373-MG cell

Author: Available in link provided

Date of Publication : Available in link provided

Water‑soluble nano‑pearl powder promotes MC3T3‑E1 cell differentiation by enhancing autophagy via the MEK/ERK signaling pathway. Molecular Medicine Reports Mol Med Rep. 2018 Jul;18(1):993-1000 WB Mouse 1:500 MC3T3-E1 cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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