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Primary Antibodies
Stat3 (Phospho-Ser727) Antibody
Stat3 (Phospho-Ser727) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A7223
Reactivity:Human,Mouse,Rat,Monkey
Applications:IF,WB,IHC,IP,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Stat3 (Phospho-Ser727) Antibody

Immunofluorescence analysis of rat-heart tissue. 1,Stat3 (phospho Ser727) Polyclonal Antibody(red) was diluted at 1:200(4°C,overnight). 2, Cy3 labled Secondary antibody was diluted at 1:300(room temperature, 50min).3, Picture B: DAPI(blue) 10min. Picture A:Target. Picture B: DAPI. Picture C: merge of A+B

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Product Details
Product Name
Stat3 (Phospho-Ser727) Antibody
Description
The protein encoded byThis gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper
Catalog No
A7223
Reactivity
Human, Mouse, Rat, Monkey
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
IF, WB, IHC, IP, ELISA
Dilution
IF 1:50-200 WB 1:500 - 1:2000. IHC 1:100 - 1:300. Immunoprecipitation: 2-5 ug:mg lysate. ELISA: 1:10000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
STAT3; APRF; Signal transducer and activator of transcription 3; Acute-phase response factor
Molecular Weight (Da or kDa)
Gene Name
STAT3
Protein Name
Signal transducer and activator of transcription 3
Human Gene ID
6774
Human Swiss Prot No.
P40763
Immunogen
The antiserum was produced against synthesized peptide derived from human STAT3 around the phosphorylation site of Ser727. AA range:694-743
Specificity
Phospho-Stat3 (S727) Polyclonal Antibody detects endogenous levels of Stat3 protein only when phosphorylated at S727.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (12)
PRKAR2A-derived circular RNAs promote the malignant transformation of colitis and distinguish patients with colitis-associated colorectal cancer Clin Transl Med. 2022 Feb;12(2):e683. WB,ISH Mouse 1: 200,1:1000 colon

Author: Available in link provided

Date of Publication : Available in link provided

Effects and Molecular Mechanism of Single-Nucleotide Polymorphisms of MEG3 on Porcine Skeletal Muscle Development. Frontiers in Genetics Front Genet. 2021 Feb;12:206 WB Porcine 1 : 1000 Porcine skeletal muscle satellite cells

Author: Available in link provided

Date of Publication : Available in link provided

Suppressed androgen receptor expression promotes M2 macrophage reprogramming through the STAT3/SOCS3 pathway. EXCLI Journal Excli J. 2019; 18: 21–29 WB Mouse 1:500 Raw264.7 cell

Author: Available in link provided

Date of Publication : Available in link provided

Inflammatory factor TNF-α promotes the growth of breast cancer via the positive feedback loop of TNFR1/NF-κB (and/or p38)/p-STAT3/HBXIP/TNFR1. Oncotarget Oncotarget. 2017 Aug 29; 8(35): 58338–58352 WB Human MDA-MB-468 cell

Author: Available in link provided

Date of Publication : Available in link provided

Cancer Stem Cells are Regulated by STAT3 Signalling in Wilms Tumour. Journal of Cancer J Cancer. 2018; 9(8): 1486–1499 WB Human,Mouse 1:1000 G401-Xenografts G401 cell

Author: Available in link provided

Date of Publication : Available in link provided

Downregulation of RIPK4 Expression Inhibits Epithelial-Mesenchymal Transition in Ovarian Cancer through IL-6. Journal of Immunology Research J Immunol Res. 2021;2021:8875450 WB Human 1 : 1000 SKOV3 cell

Author: Available in link provided

Date of Publication : Available in link provided

Tang, Qiusha, et al. "Combination of PEI-Mn0. 5Zn0. 5Fe2O4 nanoparticles and pHsp 70-HSV-TK/GCV with magnet-induced heating for treatment of hepatoma." International journal of nanomedicine 10 (2015): 7129.

Author: Available in link provided

Date of Publication : Available in link provided

N′-[(3-[benzyloxy] benzylidene]-3, 4, 5-trihydroxybenzohydrazide (1) protects mice against colitis induced by dextran sulfate sodium through inhibiting NFκB/IL-6/STAT3 pathway." Biochemical and biophysical research communications 477.2 (2016): 290-296.

Author: Available in link provided

Date of Publication : Available in link provided

miRNA-331-3p Affects the Proliferation, Metastasis, and Invasion of Osteosarcoma through SOCS1/JAK2/STAT3 Journal of Oncology Bing Wu WB Mouse

Author: Available in link provided

Date of Publication : Available in link provided

Cadmium contributes to atherosclerosis by affecting macrophage polarization FOOD AND CHEMICAL TOXICOLOGY Jia Song IHC,WB Mouse carotid RAW264.7 cells

Author: Available in link provided

Date of Publication : Available in link provided

Oxymatrine ameliorates rheumatoid arthritis by regulation of Tfr/Tfh cells balance via TLR9-MyD88-STAT3 signaling pathway. Yanli Zhang WB Mouse joint synovial tissue

Author: Available in link provided

Date of Publication : Available in link provided

M2 macrophage‑derived exosomes alleviate KCa3.1 channel expression in rapidly paced HL‑1 myocytes via the NF‑κB (p65)/STAT3 signaling pathway Molecular Medicine Reports Huiyu Chen WB Mouse 1:1000 HL-1 myocytes

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

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    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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