protein tyrosine kinase 2(PTK2) Homo sapiens This gene encodes a Cytoplasmic protein tyrosine kinase which is found concentrated in the focal adhesions that form between cells growing in the presence of Extracellular matrix constituents. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Activation of this gene may be an important early step in cell growth and intracellular signal transduction pathways triggered in response to certain neural peptides or to cell interactions with the Extracellular matrix. Several transcript variants encoding different isoforms have been found for this gene, but the full-length natures of only four of them have been determined. [provided by RefSeq, Oct 2015]
Catalog No
A8032
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Western blot analysis of lysates from HepG2 cells treated with PMA 125ng/ml 20', using FAK (Phospho-Ser843) Antibody. The lane on the right is blocked with the phospho peptide.
