The protein encoded by this gene is a member of the Toll-like receptor (TLR) family which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. The various TLRs exhibit different patterns of expression. This receptor is most abundantly expressed in Placenta and Pancreas, and is restricted to the dendritic subpopulation of the leukocytes. It recognizes dsRNA associated with viral infection, and induces the activation of NF-kappaB and the production of type I interferons. It may thus play a role in host defense against viruses. Use of alternative polyadenylation sites to generate
Catalog No
A8436
Reactivity
Human, Mouse, Rat
Applications
WB
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
WB 1:500-2000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
Toll-like receptor 3 (CD antigen CD283)
Molecular Weight (Da)
99440
Gene Name
TLR3
Protein Name
TLR3 (Phospho-Tyr759)
Human Gene ID
7098
Human Swiss Prot No.
O15455
Immunogen
Synthesized peptide derived from human TLR3 (Phospho-Tyr759)
Specificity
This antibody detects endogenous levels of TLR3 (Phospho-Tyr759) at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.166% sodium azide.
