This gene encodes the erythropoietin receptor which is a member of the cytokine receptor family. Upon erythropoietin binding, this receptor activates Jak2 tyrosine kinase which activates different intracellular pathways including: Ras/MAP kinase, phosphatidylinositol 3-kinase and STAT transcription factors. The stimulated erythropoietin receptor appears to have a role in erythroid cell survival. Defects in the erythropoietin receptor may produce erythroleukemia and familial erythrocytosis. Dysregulation of this gene may affect the growth of certain tumors. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Catalog No
A9036
Reactivity
Human, Mouse, Rat
Applications
WB, ELISA
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
EPOR; Erythropoietin receptor; EPO-R
Molecular Weight (Da)
55065
Gene Name
EPOR
Protein Name
Erythropoietin receptor
Human Gene ID
2057
Human Swiss Prot No.
P19235
Immunogen
Synthesized phospho-peptide around the phosphorylation site of human EpoR (phospho Tyr426)
Specificity
Phospho-EpoR (Y426) Polyclonal Antibody detects endogenous levels of EpoR protein only when phosphorylated at Y426.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.