The protein encoded by this gene forms a heteromeric complex with type II TGF-beta receptors when bound to TGF-beta, transducing the TGF-beta signal from the cell surface to the Cytoplasm. The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic aneurysm syndrome (LDAS). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Catalog No
A9060
Reactivity
Human, Mouse, Rat
Applications
WB
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
WB 1:500-2000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
TGF-beta receptor type-1 (TGFR-1) (EC 2.7.11.30) (Activin A receptor type II-like protein kinase of 53kD) (Activin receptor-like kinase 5) (ALK-5) (ALK5) (Serine/threonine-protein kinase receptor R4) (SKR4) (TGF-beta type I receptor) (Transforming growth factor-beta receptor type I) (TGF-beta receptor type I) (TbetaR-I)
Molecular Weight (Da)
55330
Gene Name
TGFBR1 ALK5 SKR4
Protein Name
TGFBR1 (Phospho-Thr204)
Human Gene ID
7046
Human Swiss Prot No.
P36897
Immunogen
Synthesized peptide derived from human TGFBR1 (Phospho-Thr204)
Specificity
This antibody detects endogenous levels of TGFBR1 (Phospho-Thr204) at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.103% sodium azide.
