The protein encoded by this gene is involved in the efficient repair of DNA single-strand breaks formed by exposure to ionizing radiation and alkylating agents. This protein interacts with DNA ligase III, polymerase beta and poly (ADP-ribose) polymerase to participate in the base excision repair pathway. It may play a role in DNA processing during meiogenesis and recombination in germ cells. A rare microsatellite polymorphism in this gene is associated with cancer in patients of varying radiosensitivity. [provided by RefSeq, Jul 2008]
Catalog No
A9130
Reactivity
Human, Mouse, Rat
Applications
WB
Modification
Phospho Specific
Source
Polyclonal Rabbit
Dilution
WB 1:500-2000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1)
Molecular Weight (Da)
69630
Gene Name
XRCC1
Protein Name
XRCC1 (Phospho-Thr284)
Human Gene ID
7515
Human Swiss Prot No.
P18887
Immunogen
Synthesized peptide derived from human XRCC1 (Phospho-Thr284)
Specificity
This antibody detects endogenous levels of XRCC1 (Phospho-Thr284) at Human, Mouse,Rat
Formulation
Liquid in PBS containing 50% glycerol, and 0.171% sodium azide.
