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Primary Antibodies
Chk2 (Phospho-Thr432) Antibody
Chk2 (Phospho-Thr432) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A9411
Reactivity:Human,Mouse,Rat
Applications:WB,ELISA
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

$205
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Chk2 (Phospho-Thr432) Antibody

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Product Details
Product Name
Chk2 (Phospho-Thr432) Antibody
Description
catalytic activity:ATP + a protein = ADP + a phosphoprotein.,cofactor:Magnesium.,disease:Defects in CHEK2 are associated with Li-Fraumeni syndrome 2 (LFS2) [MIM:609265]; a highly penetrant familial cancer phenotype usually associated with inherited mutations in p53/TP53.,disease:Defects in CHEK2 are found in some patients with osteosarcoma (OSRC) [MIM:259500].,disease:Defects in CHEK2 are found in some patients with prostate cancer (CaP) [MIM:176807].,enzyme regulation:Rapidly phosphorylated on Thr-68 by MLTK in response to DNA damage and to replication block. Kinase activity is also up-regulated by autophosphorylation.,function:Regulates cell cycle checkpoints and apoptosis in response to DNA damage, particularly to DNA double-strand breaks. Inhibits CDC25C phosphatase by phosphorylation on 'Ser-216', preventing the entry into mitosis. May also play a role in meiosis. Regulates the TP53 tumor suppressor through phosphorylation at 'Thr-18' and 'Ser-20'.,similarity:Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHK2 subfamily.,similarity:Contains 1 FHA domain.,similarity:Contains 1 protein kinase domain.,subcellular location:Isoform 10 is present throughout the cell.,tissue specificity:High expression is found in testis, spleen, colon and peripheral blood leukocytes. Low expression is found in other tissues.,
Catalog No
A9411
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
WB, ELISA
Dilution
WB 1:1000-2000 ELISA 1:5000-20000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
Serine/threonine-protein kinase Chk2 (EC 2.7.11.1; CHK2 checkpoint homolog; Cds1 homolog; Hucds1; hCds1; Checkpoint kinase 2)
Molecular Weight (Da or kDa)
Gene Name
CHEK2 CDS1 CHK2 RAD53
Protein Name
Chk2 (Phospho Thr432)
Human Gene ID
11200
Human Swiss Prot No.
O96017
Immunogen
Synthesized peptide derived from human Chk2 (Phospho Thr432)
Specificity
This antibody detects endogenous levels of Human,Mouse,Rat Chk2 (Phospho Thr432)
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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