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Primary Antibodies
MLKL (Phospho-S358) Antibody
MLKL (Phospho-S358) Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: A9555
Reactivity:Human
Applications:IHC,IF
Modification:Phospho Specific
Source:Store at -20°C/1 year
Storage and Stability:

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MLKL (Phospho-S358) Antibody

Immunohistochemical analysis of paraffin-embedded human small intestinal carcinoma tissue. 1,primary Antibody was diluted at 1:200(4° overnight). 2, Sodium citrate pH 6.0 was used for antigen retrieval(>98°C,20min). 3,Secondary antibody was diluted at 1:200

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Product Details
Product Name
MLKL (Phospho-S358) Antibody
Description
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],
Catalog No
A9555
Reactivity
Human
Source
Polyclonal, Rabbit,IgG
Modification
Phospho Specific
Applications
IHC, IF
Dilution
IHC 1:100-500;IF ICC 1:100-500
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
Mixed lineage kinase domain-like protein
Molecular Weight (Da or kDa)
Gene Name
MLKL
Protein Name
MLKL (phospho S358)
Human Gene ID
197259
Human Swiss Prot No.
Q8NB16
Immunogen
Synthesized peptide derived from human MLKL (phospho S358)
Specificity
This antibody detects endogenous phospho levels of MLKL (phospho S358) at Human, Mouse, Rat
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (2)
IMB5036 inhibits human pancreatic cancer growth primarily through activating necroptosis. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY Basic Clin Pharmacol. 2022 Mar;130(3):375-384 IF Human Capan-2 cell，BxPC-3 cell

Author: Available in link provided

Date of Publication : Available in link provided

iMSC exosome delivers hsa-mir-125b-5p and strengthens acidosis resilience through suppression of Asic1 protein in cerebral ischemia-reperfusion JOURNAL OF BIOLOGICAL CHEMISTRY Kai Dong WB Rat neurons

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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