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> Products > Primary Antibodies > CAS Antibody

CAS Antibody

Overview Description
Datasheet SDS
   Tumor Suppressors/Apoptosis   
Catalog No : C0146
  • Reactivity
    Human,Rat,Mouse
  • Applications
    WB,IHC-p,IP,IF/ICC,ELISA
  • Modification
    Unmodified/Total
  • Source
    Polyclonal Rabbit
  • Storage and Stability
    -20°C/1 year
  • Size
    50 μl
  • Price/Quantity
    $205
  • Quantity
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Details
  • Product Name
    CAS Antibody
  • Description
    Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the Cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the Cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]
  • Catalog No
    C0146
  • Reactivity
    Human, Rat, Mouse
  • Applications
    WB, IHC-p, IP, IF/ICC, ELISA
  • Modification
    Unmodified/Total
  • Source
    Polyclonal Rabbit
  • Dilution
    Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunoprecipitation: 2-5 ug/mg lysate. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
  • Purification
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • Concentration
    1 mg/ml
  • Storage and Stability
    -20°C/1 year
  • Other Name
    CSE1L; CAS; XPO2; Exportin-2; Exp2; Cellular apoptosis susceptibility protein; Chromosome segregation 1-like protein; Importin-alpha re-exporter
  • Molecular Weight (Da)
    110417
  • Gene Name
    CSE1L
  • Protein Name
    Exportin-2
  • Human Gene ID
    1434
  • Human Swiss Prot No.
    P55060
  • Immunogen
    The antiserum was produced against synthesized peptide derived from human CSE1L. AA range:1-50
  • Specificity
    CAS Polyclonal Antibody detects endogenous levels of CAS protein.
  • Formulation
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Application Data
Western blot analysis of lysates from 293 cells, using CSE1L Antibody. The lane on the right is blocked with the synthesized peptide.
Application Data
Immunohistochemistry analysis of paraffin-embedded human brain tissue, using CSE1L Antibody. The picture on the right is blocked with the synthesized peptide.
Application Data
Immunofluorescence analysis of HeLa cells, using CSE1L Antibody. The picture on the right is blocked with the synthesized peptide.
Application Data
Western Blot analysis of various cells using CAS Polyclonal Antibody diluted at 1:2000

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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