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Primary Antibodies
ASC Antibody
ASC Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C11888
Reactivity:Human,Mouse,Rat
Applications:WB,IHC-p,IF/ICC,ELISA
Modification:Unmodified/Total
Source:Polyclonal Rabbit
Storage and Stability:-20°C/1 year

$205
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Tumor Suppressors/Apoptosis
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ASC Antibody

Western blot analysis of lysates from 1) K562, 2) Hela, 3) 3T3 cells, （Green） primary antibody was diluted at 1:1000, 4°over night, secondary antibody(cat:SA0439)was diluted at 1:10000, 37° 1hour. （Red） Tubulin β Monoclonal Antibody(5G3) (cat:N1294) antibody was diluted at 1:5000 as loading control, 4° over night,secondary antibody(cat:SA0436)was diluted at 1:10000, 37° 1hour.

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Product Details
Product Name
ASC Antibody
Description
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the Cytoplasm; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Catalog No
C11888
Reactivity
Human, Mouse, Rat
Applications
WB, IHC-p, IF/ICC, ELISA
Modification
Unmodified/Total
Source
Polyclonal Rabbit
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
PYCARD; ASC; CARD5; TMS1; Apoptosis-associated speck-like protein containing a CARD; hASC; Caspase recruitment domain-containing protein 5; PYD and CARD domain-containing protein; Target of methylation-induced silencing 1
Molecular Weight (Da)
21627
Gene Name
PYCARD
Protein Name
Apoptosis-associated speck-like protein containing a CARD
Human Gene ID
29108
Human Swiss Prot No.
Q9ULZ3
Immunogen
The antiserum was produced against synthesized peptide derived from human ASC. AA range:10-59
Specificity
ASC Polyclonal Antibody detects endogenous levels of ASC protein.
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (20)
Noise exposure and its relationship with postinfarction cardiac remodeling: implications for NLRP3 inflammasome activation

Author: Yanzhao Wei, Wei Li, Shuang Yang, Peng Zhong, Yingying Bi, Yanhong Tang

Date of Publication : 2022-05-16

Metadherin silencing results in the inhibition of pyroptosis in lipopolysaccharide/adenosine triphosphate − stimulated renal tubular epithelial cells

Author: Xiuping Duan, Yashan Song, Fuji Li, Yunhua Liao, Wenting Liu

Date of Publication : 2021-12-27

Micro RNAs 26b, 20a inversely correlate with GSK-3 β/NF-κB/NLRP-3 pathway to highlight the additive promising effects of atorvastatin and quercetin in experimental induced arthritis

Author: Sherihan Salaheldin Abdelhamid Ibrahim, Lamia Said Kandil, Ghada M. Ragab, Shorouk M. El-Sayyad

Date of Publication : 2021-08-13

Reactive oxygen species induced by uric acid promote NRK‑52E cell apoptosis through the NEK7‑NLRP3 signaling pathway

Author: Dongdong Li, Luobing Wang, Jiaoying Ou, Chuanxu Wang, Jiabao Zhou, Lili Lu, Yanshneg Wu, Jiandong Gao

Date of Publication : 2021-08-13

TRPV4 Regulates Soman-Induced Status Epilepticus and Secondary Brain Injury via NMDA Receptor and NLRP3 Inflammasome

Author: Wang, Shuai, He, Huanhuan, Long, Jianhai, Sui, Xin, Yang, Jun, Lin, Guodong, Wang, Qian, Wang, Yongan, Luo, Yuan

Date of Publication : 2021-03-24

A selective NLRP3 inflammasome inhibitor attenuates behavioral deficits and neuroinflammation in a mouse model of Parkinson's disease

Author: Shuxuan Huang, Zhi Chen, Binglin Fan, Yuan Chen, Liyuan Zhou, Bingjian Jiang, Haiyin Long, Weizhang Zhong, Xiaofeng Li, Yanhua Li

Date of Publication : 2021-03-08

Berberine Protects Against NLRP3 Inflammasome via Ameliorating Autophagic Impairment in MPTP-Induced Parkinson’s Disease Model

Author: Huang Shuxuan, Liu Hanqun, Lin Yuwan, Liu Muchang, Li Yanhua, Mao Hengxu, Zhang Zhiling, Zhang Yunlong, Ye Panghai, Ding Liuyan, Zhu Ziting, Yang Xinling, Chen Chaojun, Zhu Xiaoqin, Huang Xiaoyun, Guo Wenyuan, Xu Pingyi, Lu Lin

Date of Publication : 2021-01-27

Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages

Author: Dongdong Wu, Hui Zhang, Qiuge Wu, Fang Li, Yang Wang, Shuai Liu, Jing Wang

Date of Publication : 2020-12-24

MCC950 Inhibits NLRP3 Inflammasome and Alleviates Axonal Injures in Early Stages of Diffuse Axonal Injury in Rats

Author: Zhao, Junjie, Guo, Xiaoye, Wang, Bo, Yang, Zhongbo, Huang, Tingqin, Guo, Dan, Zhang, Ming, Song, Jinning

Date of Publication : 2020-05-30

NLRP3 inflammasome and endoplasmic reticulum stress in the epileptogenic zone in temporal lobe epilepsy: molecular insights into their interdependence

Author: J. Yue, Y. J. Wei, X. L. Yang, S. Y. Liu, H. Yang, C. ‐Q. Zhang

Date of Publication : 2020-05-08

Geniposide inhibits NLRP3 inflammasome activation via autophagy in BV-2 microglial cells exposed to oxygen–glucose deprivation/reoxygenation

Author: Chen Fu, Xinyang Zhang, Yao Lu, Fengli Wang, Zhenmin Xu, Shaojiao Liu, Hong Zheng, Xuemei Liu

Date of Publication : 2020-04-30

Decreased expression of Rev-Erbα in the epileptic foci of temporal lobe epilepsy and activation of Rev-Erbα have anti-inflammatory and neuroprotective effects in the pilocarpine model

Author: Jiong Yue, Jiaojiang He, Yujia Wei, Kaifeng Shen, Kefu Wu, Xiaolin Yang, Shiyong Liu, Chunqing Zhang, Hui Yang

Date of Publication : 2020-01-31

NPY Receptor 2 Mediates NPY Antidepressant Effect in the mPFC of LPS Rat by Suppressing NLRP3 Signaling Pathway

Author: Wang Wenjiao, Xu Tao, Chen Xinyue, Dong Kemeng, Du Chunkai, Sun Jing, Shi Cuige, Li Xiaoxiao, Yang Yutao, Li Hui, Xu Zhi-Qing David

Date of Publication : 2019-05-15

Functional characterization of a potent anti-tumor polysaccharide in a mouse model of gastric cancer

Author: 0

Date of Publication : 2019-01-03

Paeonia lactiflora Pall. regulates the NF‐κB‐NLRP3 inflammasome pathway to alleviate cholestasis in rats

Author: Ma Xiao, Wen Jian-Xia, Gao Si-Jia, He Xuan, Li Peng-Yan, Yang Yu-Xue, Wei Shi-zhang, Zhao Yan-Ling, Xiao Xiao-He

Date of Publication : 2018-09-14

Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel

Author: Ying Li, Jiang Wu, Yang Niu, Honghao Chen, Qingya Tang, Yan Zhong, Tim T. Lambers, Wei Cai

Date of Publication : 2018-08-24

Esculetin inhibits the pyroptosis of microvascular endothelial cells through NF-κB /NLRP3 signaling pathway

Author: Wei Ren, Qilyu Zhou, Ruyang Yu, Zhongjie Liu, Yusheng Hu

Date of Publication : 44634

HDAC11 promotes both NLRP3/caspase-1/GSDMD and caspase-3/GSDME pathways causing pyroptosis via ERG in vascular endothelial cells

Author: Yao, Feng, Jin, Zhen, Zheng, Zihan, Lv, Xiaohan, Ren, Lingxuan, Yang, Jianjun, Chen, Danli, Wang, Bo, Yang, Wei, Chen, Lifang, Wang, Weirong, Gu, Jianli, Lin, Rong

Date of Publication : 44632

Attenuation of Oxidative Stress-Induced Cell Apoptosis and Pyroptosis in RSC96 Cells by Salvianolic Acid B

Author: Wang, Qian-qian, Wang, Meng, Li, Yan, Liu, Yong-hui, Sun, Lian-qing

Date of Publication : 44588

Effects of Hypoxic Environment on Periodontal Tissue through the ROS/TXNIP/NLRP3 Inflammasome Pathway

Author: Zhu Rui, Mi Xiaohui, Li Yongming

Date of Publication : 44578

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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