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Primary Antibodies
PARP-1 Antibody
PARP-1 Antibody

Assay Biotechnology Inc Antibodies and ELISA Kits have been rigorously validated for laboratory grade quality results. High specificity paired with high affinity for targets of interest give researchers an advantage with our products

Catalog No: C21676
Reactivity:Human,Mouse,Rat
Applications:IHC,IF,WB
Modification:Unmodified/Total
Source:Polyclonal,Rabbit,IgG
Storage and Stability:Store at -20°C/1 year

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PARP-1 Antibody

Immunohistochemical analysis of paraffin-embedded human brain. 1, Tris-EDTA,pH9.0 was used for antigen retrieval. 2 Antibody was diluted at 1:200(4° overnight.3,Secondary antibody was diluted at 1:200(room temperature, 45min).

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Product Details
Product Name
PARP-1 Antibody
Description
This gene encodes a chromatin-associated enzyme, poly(ADP-ribosyl)transferase, which modifies various nuclear proteins by poly(ADP-ribosyl)ation. The modification is dependent on DNA and is involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation and also in the regulation of the molecular events involved in the recovery of cell from DNA damage. In addition, this enzyme may be the site of mutation in Fanconi anemia, and may participate in the pathophysiology of type I diabetes. [provided by RefSeq, Jul 2008],
Catalog No
C21676
Reactivity
Human, Mouse, Rat
Source
Polyclonal, Rabbit,IgG
Modification
Unmodified/Total
Applications
IHC, IF, WB
Dilution
IHC 1:50-200, WB 1:500-2000. IF 1:50-200
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Storage and Stability
Store at -20°C/1 year
Other Name
Poly [ADP-ribose] polymerase 1 (PARP-1; EC 2.4.2.30; ADP-ribosyltransferase diphtheria toxin-like 1; ARTD1; NAD(+) ADP-ribosyltransferase 1; ADPRT 1; Poly[ADP-ribose] synthase 1)
Molecular Weight (Da or kDa)
Gene Name
PARP1 ADPRT PPOL
Protein Name
PARP-1
Human Gene ID
142
Human Swiss Prot No.
P09874
Immunogen
Synthesized peptide derived from human PARP-1. AA range: 410-460
Specificity
This antibody detects endogenous levels of human PARP-1
Formulation
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
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Publications (7)
The degradation of mixed lineage kinase domain-like protein promotes neuroprotection after ischemic brain injury. Oncotarget Oncotarget. 2017 Sep 15; 8(40): 68393–68401 WB Mouse hemisphere tissue

Author: Available in link provided

Date of Publication : Available in link provided

Synergistic Apoptotic Effect of D-Fraction From Grifola frondosa and Vitamin C on Hepatocellular Carcinoma SMMC-7721 Cells:. INTEGRATIVE CANCER THERAPIES 2016 May 05 WB Human SMMC-7721 cell

Author: Available in link provided

Date of Publication : Available in link provided

Aaptamine attenuates the proliferation and progression of non-small cell lung carcinoma. PHARMACEUTICAL BIOLOGY Pharm Biol. 2020;58(1):1044-1054 WB Human A549 cell，H1299 cell

Author: Available in link provided

Date of Publication : Available in link provided

PARP inhibitor re‑sensitizes Adriamycin resistant leukemia cells through DNA damage and apoptosis. Molecular Medicine Reports Mol Med Rep. 2019 Jan;19(1):75-84 WB Human 1:1000 K562/ADR cell

Author: Available in link provided

Date of Publication : Available in link provided

Marine bromophenol bis (2, 3-dibromo-4, 5-dihydroxybenzyl) ether, represses angiogenesis in HUVEC cells and in zebrafish embryos via inhibiting the VEGF signal systems." Biomedicine & Pharmacotherapy 75 (2015): 58-66.

Author: Available in link provided

Date of Publication : Available in link provided

Coptisine Induces Apoptosis in Human Hepatoma Cells Through Activating 67-kDa Laminin Receptor/cGMP Signaling. Frontiers in Pharmacology 2018 May 18 WB Human 1:500 SMMC7721 cell, HepG2 Cell

Author: Available in link provided

Date of Publication : Available in link provided

High expression of PINK1 promotes proliferation and chemoresistance of NSCLC. ONCOLOGY REPORTS Oncol Rep. 2017 Apr;37(4):2137-2146 WB Human NSCLC tissues A549 cell, H1299 cell

Author: Available in link provided

Date of Publication : Available in link provided

Primary Antibodies

    • ELISA Kits

    • Research Areas

    Cell Adhesion Proteins Cell Cycle Proteins Channel Proteins Exosome GDP/GTP Binding Proteins Growth Factors and Hormones Homeodomain Proteins Immunohistochemical Kinases and Phosphatases Signaling

     

    Membrane Receptors Neurobiology Signaling Intermediates Steroid Receptors Structural Proteins Synthesis and Degradation Transcription Regulators Transport and Trafficking Tumor Suppressors/Apoptosis
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