The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can media
Catalog No
D12058
Reactivity
Human:K120, Mouse:K115, Rat:K118
Applications
WB, ELISA
Modification
Acetyl Specific
Source
Polyclonal Rabbit
Dilution
WB: 1:500-10000 ELISA: 1:10000
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Storage and Stability
-20°C/1 year
Other Name
E2F1 RBBP3
Molecular Weight (Da)
46920
Gene Name
E2F1 RBBP3
Protein Name
E2F transcription factor 1
Human Gene ID
1869
Human Swiss Prot No.
Q01094
Immunogen
Synthesized acetyl-peptide from human protein at AA range: 100-170
Specificity
The antibody detects endogenous E2F-1 (Acetyl-Lys120) protein
Formulation
PBS, pH 7.4, containing 0.02% sodium azide as Preservative and 50% Glycerol.
